Tag: Ajinomoto

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‘Likely Culprit’ in Celiac Disease Hidden in Processed Foods

Why is Ajinomoto trying so hard to keep transglutaminase unlabeled?

Over the past few decades celiac disease (CD) has morphed into a “major public health problem.” Along with it, other autoimmune conditions such as diabetes, rheumatoid arthritis, inflammatory bowel disease and psoriasis, are also topping the charts as very common disorders with dozens of heavily advertised drugs created to treat them.

If you ask why, the knee-jerk response is typically that better testing has uncovered all these otherwise undisclosed conditions. But does that really explain things? And it certainly doesn’t take into consideration what experts refer to as large numbers of people with undiagnosed autoimmune diseases, especially CD.

Back in 2015 two researchers with expertise in metabolic diseases, Aaron Lerner, a professor at Tel Aviv University, and Torsten Matthias, affiliated with the AESKU.KIPP Institute in Germany, first sounded the alarm on a largely unknown, widely used food additive – an enzyme called transglutaminase (TG). At that time, they proposed a “hypothesis” linking TG used in food processing to celiac and other autoimmune diseases. Four years later, however, the pair stated that further research and observations have closed the “gaps” in our understanding of how TG is an “inducer of celiac disease.”   

Big Food’s favorite find to ‘glue’ things together

Transglutaminase, a.k.a. “meat glue,” is the darling of Big Food for lots of reasons: it can glue together scraps of fish, chicken and meat into whole-looking cuts (often called “Frankenmeats”); extend the shelf life of processed foods (even pasta); improve “texture,” especially in low-salt, low-fat products; make breads and pastries (particularly gluten-free ones) rise better, and, as one manufacturer puts it, allow for use of things that would ordinarily be tossed out — unappetizing leftovers and scraps of food that would “otherwise be considered waste ingredients, creating an added-value product.”

But more than just turning “waste ingredients” into new food products, there are a host of other reasons why you should do your best to steer clear of meat glue.

‘Tight junction dysfunction’

The 2015 research published by Lerner and Matthias detailed how certain food additives may be behind the steady rise of autoimmune diseases due to something called “tight junction dysfunctions,” which can set the stage for a wide variety of serious ailments, calling out transglutaminase as one of the commonly used food additives that can enhance “intestinal junction leakage.”

A subsequent study in 2019 recognized transglutaminase as a “likely culprit” in celiac disease.

In 2020, Lerner and Matthias published yet another paper on transglutaminase and celiac disease, calling it a “potential public health concern” and saying that they hope their review will “encourage clinical, scientific and regulatory debates on (its) safety to protect the public.”

Despite all the warnings and additional research, use of the enzyme is booming, and all its food uses are now considered GRAS (generally recognized as safe) by the FDA.

TG and MSG

The similarities between MSG and transglutaminase are quite noteworthy. Not only is the enzyme manufactured in great quantities by Ajinomoto (as is MSG) but the way TG is promoted by the company is remarkably similar to its long-running propaganda campaign claiming that MSG is a safe ingredient.

For example, Ajinomoto states on its websites and elsewhere that both MSG and TG are “found in food naturally,” are “safe,” used in many countries and considered GRAS in the U.S. by the FDA. And just as MSG supposedly in no way causes serious reactions, the company says that TG in no way causes celiac disease – in fact, under some circumstances the TG added to food can actually help CD patients, Ajinomoto says.

While transglutaminase is found naturally in the human body (as is glutamate), there is a significant difference between microbial TG (the manufactured additive) and “our own transglutaminase” says Lerner.  (Just as there is a major difference between manufactured MSG and the glutamate in your body).

That’s because the tissue TG produced in the body “has a different structure (from) the microbial sort, which allows its activity to be tightly controlled. Microbial transglutaminase itself could also increase intestinal permeability,” he says, “by directly modifying proteins that hold together the intestinal barrier.”

The FDA has “no questions”

Once the FDA pretended to look into the safety of a product before granting it GRAS status, but not even that is done any more.  Now a company simply turns in a statement that a product should be referred to as GRAS, and it’s done.

Starting in 1998 Ajinomoto filed four notices of “self-determined” GRAS status for TG with the FDA. The first was to use TG in seafood. In 1999 they sent in more intended uses for hard and soft cheeses, yogurt, and “vegetable protein dishes/veggie burgers/meat substitutes.” In 2000 Ajinomoto sent another notice to the FDA regarding using transglutaminase in pasta, bread, pastries, ready-to-eat cereal, pizza dough and “grain mixtures.”

And in 2002, Ajinomoto asked that anything else it might have previously overlooked, referred to as “use in food in general,” be given GRAS status. None of these GRAS notices elicited any objections from the FDA.  Nothing that Big Food asks for is even questioned any more.

Included in the 2001 “everything else” notification from Ajinomoto were some details of a 30-day toxicity study using beagles. Despite findings that included dogs that had developed a pituitary gland cyst, discoloration of the lungs, an enlarged uterus and “significantly” lower prostate weights, all that was considered “incidental and unrelated” to TG. Why they bothered to include a study that shows that their product causes harm to the animals studied can only be understood if you know how Ajinomoto operates.  Having done a study, they can later refer to the study that they did as though it proved that their product was “safe,” knowing that no one will challenge them. Such claims have great propaganda value.

The FDA had “no questions.”

Transglutaminase, here, there and everywhere

Lerner and Matthias have been warning for years about TG hidden in processed foods, saying it’s “unlabeled and hidden from public knowledge.” As we mentioned in another blog on TG, aside from “formed” meat products sold in supermarkets in the U.S. where the enzyme must be called out on the ingredient statement, TG can easily go undercover. 

And Ajinomoto has even added its own tips to help food manufacturers avoid labeling by providing an explanation of how TG is just a “processing aid,” as well as making available a letter authored by a law firm in Germany stating that aside from use in “formed” meat or fish, transglutaminase is “no ingredient” and as such in the EU does not have to be included on a food label. In fact, the lawyers go so far as to state that if a substance (such as TG) is “without any function in the finished product,” listing it on the ingredient label can “mislead the consumer.”

The FDA told us that if TG is used as a “processing aid” it’s considered an “incidental additive” and is “exempted from ingredient labeling.”

Even organic products aren’t safe from TG, as TG is considered A-OK to use it in organic foods, falling under the “allowed” generic category of “enzymes” on the USDA “National list of allowed and prohibited substances” in organic food and farming.

Perhaps the most devious use of this enzyme is to improve the appearance of gluten-free bakery products. Manufactured, microbial transglutaminase “functionally imitates” natural-tissue TG, which is known to be an autoantigen (a “self” antigen, reacting to something produced by the body that provokes an immune response) in those who suffer from celiac disease.  

Steering clear of transglutaminase

The TG story could very well be called a case against processed foods, as the only sure-fire way to avoid this gut-wrenching enzyme is to make/cook all your food from scratch. That being a very unlikely prospect these days, the next best thing is to avoid the following:

  • Low-fat and low-salt products, especially dairy and dairy substitutes;
  • Chicken nuggets, along with any other “formed” meat products;
  • Expensive cuts of meat being sold much cheaper than they should be (that especially is true for restaurants);
  • Sushi from unreliable sources, formed fish sticks and balls;
  • Veggie and tofu burgers; and
  • Cheaply produced pasta (TG is said to help when using “damaged wheat flour”).

When asked what he would consider to be an important take-away regarding transglutaminase, Professor Lerner told us that it would be for the FDA to “reconsider the classification of (manufactured) TG as GRAS.”

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New name for an old poison

It’s obvious that your PR campaign is working really well when you can influence the Merriam-Webster dictionary to modify the definition of a long-used word.

Such is the case with “savory,” a respectable word meaning pleasant or having high moral standards. In a food sense, savory can be two types of aromatic mints as well as a tasty food that is “spicy or salty but not sweet.” And that’s how savory was defined for a very long time, its first known use being in the 13th century.

But at some point in 2019, as confirmed by the Internet archive way-back machine, Merriam-Webster added additional meanings that include none other than the all-time favorite word of the glutamate industry – umami – now defining savory as the “…taste sensation of umami” and the “taste sensation that is produced by several amino acids and nucleotides (such as glutamate and aspartate)…” (For more on “umami” check out our blog “Umami: the con of the decade?” here).

Savory is also utilized in what’s called the “savory market,” not surprisingly consisting of ingredients that all contain excitotoxic, brain damaging, free glutamic acid, such as: yeast extracts, hydrolyzed vegetable proteins, hydrolyzed animal proteins, monosodium glutamate, and nucleotides.

And that “savory market,” according to a new research report is booming. Of interest, included in that report are references to not just people food, but pet food as well. That makes careful label reading an important part of buying food for all members of your family.

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The birth of brain-damaging amino acids

Prior to 1957, excitotoxity did not exist.  For amino acids to be brain-damaging (excitotoxic), amino acids had to be available in excess of what the body required for normal body function. 

Before man began to manufacture amino acids, animals got the amino acids that they needed by eating amino acid-rich food found in the environment, or amino acids were produced by the body as needed. 

For amino acids to become excitotoxic amino acids, they had to be available in quantity – in “excess.”  And prior to the production/manufacture of amino acids in 1957, there were no “excess” amino acids. Before 1957, there was no such thing as excitotoxicity.

The concept of excitotoxic amino acids evolved from the work of John Olney, who had observed that immature mice fed or administered large quantities of free amino acids became grotesquely obese. 

Through animal studies done in the 1960s and 1970s, Olney and others demonstrated that free glutamate passed by mothers to immature infants causes brain damage, endocrine disruption, and behavior disorders when fed in “excess” to the animals, and Olney coined the word “excitotoxin” to describe the phenomenon.  Although not interested in food science, researchers of that period used monosodium glutamate (MSG) for its free glutamate content, for they had observed that brain damage could be caused by the relatively inexpensive free glutamate in MSG as well as by more expensive pharmaceutical-grade glutamate.

The reaction of the manufacturer of MSG

Olney was a neuroscientist interested in such things as amino acids and brain function and had no interest in food science per se.

But those who manufactured and profited from the sale of MSG knew that their product, monosodium glutamate, had been used as the source of free glutamate that caused brain damage.  And they set about to do whatever it might take to convince the public that MSG was a harmless, or even beneficial, food additive. 

In 1969, the fact that monosodium glutamate had been used as the source of free glutamate that caused brain damage, became a well-guarded secret — a secret vigorously protected by the people who, in 1957, produced the first excitotoxins.

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MSG on 60 Minutes got people riled up 30 years ago. Could it do the same thing today?

Thirty years ago this 60 Minutes program (video below) on MSG was the second most-watched show of the year. Despite that, the show’s creator Don Hewitt caved to glutamate-industry pressure and refused to air it a second time.

Since then the Glutes have kept a tight wrap on information about the toxic effects of MSG, filling the Internet, newspapers and TV with cleverly crafted propaganda that carries the falsehood MSG is a harmless ingredient. Advertising studies have been rigged to conclude that nothing was found to suggest that MSG is anything other than safe, diverting funding from research that might concluded that MSG is harmful, enlisting the support of celebrities and professionals who vouch for the safety of their excitotoxic – brain damaging – product and keeping any mention of possible MSG-toxicity out of FDA files.

But it’s a new day. And as much as we may disagree about our politics and even what truth is, no one will disagree with the notion that it’s wrong to poison people, most especially our children. And so, through a Citizen Petition addressed to FDA Commissioner Hahn, I have asked the people at the FDA (who have kept the myth of the safety of MSG alive no matter what) to weed out the lies that the FDA is telling at the behest of the glutamate industry and officially stop calling the excitotoxic manufactured glutamic acid and the MSG that contains it generally recognized as safe — GRAS.

To comment on and support that petition, simply go here and then click the blue “comment now” button at the top of the page.

And be sure to share this message with Facebook, Twitter and LinkedIn friends.

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Who are the ‘Glutes’?

For years, the Truth in Labeling Campaign has been calling them the “Glutes,” a name that many now recognize as being those who make money selling their poisons hidden in food. We gave them a name because we want you to know them and start talking about them, and it’s hard to talk about someone or something if it doesn’t have a name.

The founder and chief operating officer of this loosely knit operation is Ajinomoto, the world’s largest producer of monosodium glutamate. Ajinomoto designs and bankrolls its research, bragging of the millions it’s spending on public relations to “clear MSG’s bad name.” Their goal is to counter the fact that every day more and more people are suffering reactions to MSG and other flavor enhancers that contain MSG’s toxic manufactured free glutamate (MfG) by plastering the world with propaganda that MSG has gotten a bad rap.

Without the researchers who execute their double-blind studies using excitotoxic, brain damaging placebos, without the food technologists who incorporate MfG into thousands of processed foods, without the manufacturers that use MSG in their products so they can skimp on quality — aided by the grocery outlets that sell their products — and without the “public servants” at the FDA who for 50 years have turned their backs on research that clearly demonstrates MSG has toxic potential while endorsing the out and out lie that MSG is safe for use in food, MSG would have long ago been banned. And it can be done. As recently as 2018 the FDA acted to no longer allow the use of seven flavoring substances and flavor enhancers deemed dangerous.

Those are the Glutes: the people who work to keep MSG flowing without mentioning that they work for the producer of MSG when signing off on their work.

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If MSG is ‘natural’ why have hundreds of patents been issued for methods of producing it?

Monosodium glutamate (MSG) found in an animal, vegetable, or mineral was manufactured and then ingested or added in some manner.

Below are just three examples of patents pertaining to the manufacture of MSG. There are literally hundreds more. MSG is man-made.

1. US3281247A – Process for producing monosodium glutamate

https://patents.google.com/patent/US3281247A/en

2. CN104211611A – New fermentation technology of sodium glutamate

https://patents.google.com/patent/CN104211611A/en

3. WO1996031459A1 – A process for the preparation of monosodium glutamate

https://patents.google.com/patent/WO1996031459A1/en

Below are general discussions pertaining to methods used in production of MSG (written by scientists, not by Ajinomoto’s hired hands).

1. Optimization of glutamic acid production by Corynebacterium glutamicum using response surface methodology

Naiyf S. Alharbia, Shine Kadaikunnana, Jamal M. Khaleda, Taghreed N. Almanaaa,Ganesh Moorthy Innasimuthub, Baskar Rajooc, Khalid F. Alanzia, Shyam Kumar Rajaram.

Journal of King Saud University – Science. Volume 32, Issue 2, March 2020, Pages 1403-1408.

https://www.sciencedirect.com/science/article/pii/S1018364719318440

2. Tasty waste: industrial fermentation and the creative destruction of MSG

Sarah E. Tracy

Food, Culture & Society (2019). 22:5, 548-65,

https://doi.org/10.1080/15528014.2019.1638117

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The Jekyll and Hyde amino acid

There’s good glutamate and bad glutamate.  Everyone needs the glutamic acid (a.k.a. glutamate) that the human body has been creating in carefully controlled amounts since time began.  It’s a building block of protein.  It’s essential to life itself. 

But manufactured free glutamate is a different thing. It was invented in 1957, at which time mass production of manufactured free glutamate began.  And from that time forward, manufactured free glutamate has been easily available in foods, drinks, supplements and drugs, in the uncontrolled amounts that cause brain damage.

Amino acids did not cause brain damage before 1957.

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If the ‘dose makes the poison’ there’s more than enough MSG and MSG-aliases in processed food to cause brain damage as well as serious observable reactions

There’s more than enough excitotoxic glutamic acid (a.k.a. free glutamate) in processed foods to create the excesses needed to cause brain damage, obesity, reproductive dysfunction, migraine headache, heart irregularities, irritable bowel, nausea and vomiting, asthma, seizures and more. In fact, excitotoxic glutamate has been known to trigger all the reactions listed as side effects of prescription drugs.

It hasn’t always been that way.

Prior to 1957, free glutamate available to people in the U.S. came largely from use of a product called Accent, which is pure MSG marketed as a flavor enhancer. In 1957, however, Ajinomoto’s method of glutamate production changed from extraction from a protein source (a slow and costly method), to a technique of bacterial fermentation wherein carefully selected genetically modified bacteria secreted glutamate through their cell walls — which enabled virtually unlimited production of MSG, allowing Ajinomoto to market its product aggressively.

It wasn’t long before Big Food discovered that increased profits could be generated by liberally using flavor enhancers (which all contain free glutamate) in every processed food product imaginable. And over the next two decades, the marketplace became flooded with manufactured/processed free-glutamate added to processed foods in ingredients such as hydrolyzed proteins, yeast extracts, maltodextrin, soy protein isolate, and MSG.

Today, more free glutamate than ever before will be found in ingredients used in processed and ultra-processed foods, snacks, and protein-fortified foods, protein drinks and shakes, and protein bars. And hydrolyzed proteins such as pea protein powder and mung bean protein isolate contain all three excitotoxic (brain-damaging) amino acids: aspartic acid (as in aspartame) and L-cysteine (used in dough conditioners), as well as glutamic acid. On top of that, excitotoxins marketed as “protein” sources have become increasingly available and extremely popular.

Recently we have seen excitotoxic amino acids in products such as Real Egg (mung bean protein isolate, the enzyme transglutaminase, and natural flavors), the Impossible Burger (textured wheat protein, potato protein, natural flavors, yeast extract, and soy protein isolate), Beyond Meat Beast Burger (pea protein isolate, natural flavoring, yeast extract, and maltodextrin), and the Lightlife Burger (water, pea protein, expeller pressed canola oil, modified corn starch, modified cellulose, yeast extract, virgin coconut oil, sea salt, natural flavor, beet powder (color), ascorbic acid (to promote color retention), onion extract, onion powder garlic powder) as well as excitotoxins added to an increasing array of ultra-processed foods. Most ultra-processed foods are made exclusively of chemicals and poor-quality ingredients to which glutamate-containing flavor enhancers have been added.

Prior to the time that Ajinomoto reformulated its method of MSG production (now over 60 years ago), accumulating excesses of glutamate through food sufficient to turn it excitotoxic would have been nearly impossible. But in the decades that followed Ajinomoto’s reformulation of MSG, obesity and infertility escalated to epidemic proportions.

The names of ingredients that contain manufactured free glutamate (MfG) can be found at this link.

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Leaked files

The Washington Post is a great source of information.  Every once in a while they run a propaganda piece for the glutamate industry that gives us a chance to see if the Glutes have come up with anything to augment their Six Big Fat Lies.  

Yesterday they ran “Leaked files reveal reputation-management firm’s deceptive tactics,” discussing a Spain-based company that made millions of dollars using bogus copyright claims, fake news sites and search engine manipulation to remake the online images of more than 1,500 clients over six years.  Ajinomoto brags about using Edelman PR.  I wonder if they use Eliminalia too.

Reference:

https://restofworld.org/2022/documents-reputation-laundering-firm-eliminalia/

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Is it news or is it propaganda?

If you have enough money and the right contacts, you too can make up your own ‘news’     

Ajinomoto, the world’s largest manufacturer of monosodium glutamate (MSG), and its PR firm, Edelman Public Relations, have recently joined with CBS to recycle the Glues favorite propaganda pieces disguised as news.

Aired recently on both CBS Mornings and the network’s highly regarded Sunday Morning show led by veteran journalist Jane Pauley, as well as a Bay area affiliate station, the productions are straight out of the Edelman/Ajinomoto playbook.

The often-repeated blueprint goes like this:”

  1. Use a headline that shows there’s controversy, but not to worry because you can trust that this article/video will give you the real facts:

Yes, MSG has a bad reputation but it’s now making a “comeback.”

“Science” has proven that there’s nothing to worry about!

Things need to be “set straight.”

2. Repeat the well-worn fiction that a 55-year-old letter is responsible for consumers considering that MSG might be toxic. Capitalize on its unique name “Chinese Restaurant Syndrome.”  Ignore the multitude of studies clearly demonstrating that MSG causes brain damage.

3. Trot out the “Expert,” who talks about “The Letter” and alludes to how it’s been refuted by “decades of research,” without the expert actually citing any.

4. Bring on the “Chefs,” who will be shown cooking up a storm of delicious food sprinkled with MSG and give some to the reporter to taste. “Yum!”

5. Introduce the xenophobic zinger. This is indeed the perfect example of the diabolical genius of the folks at Edelman PR, filling the airwaves with the concept that avoidance of MSG isn’t based on science, but is actually nothing more than anti-Asian hate speech in disguise.

“Ajinomoto established that deep-rooted xenophobia is at the center of MSG’s complicated history in the U.S.” Edelman stated in a 2019 press release. That seemingly crazy concept has caught on so well that even a book I co-authored about food additives was targeted by a “reader review” that claimed it’s “not cool to promote myths rooted in racism.”

The Edelman team works long and hard at selling the product they’ve been paid to sell. And they have the media connections to make it happen. But despite the constant use of such expensive and wide-spread propaganda, recognition that MSG is harmful continues to be acknowledged by consumers. It looks like growing numbers of consumers are realizing that they are getting sick following meals that include MSG or some other ingredient that contains its processed free glutamate, and that the more consumers know the harder Ajinomoto and Edelman will work to sell us its disinformation.  Remember that currently the only consumer group to reveal what’s going on with MSG is the Truth in Labeling Campaign.

Interesting thing about CBS, the network also makes itself available to spin news on behalf of Big Pharma.  A January 60 Minutes program was identified as “an unlawful weight loss drug ad” for the med Wegovy by the Physicians Committee for Responsible Medicine. “The 60 Minutes program looked like a news story, but it was effectively a drug ad,” the group Committee said in a press release. PCRM also stated that Novo Nordisk, which makes Wegovy, paid over $100,000 to the doctors CBS interviewed for the segment.

The blog links below (click on the headlines) will give you an idea of how extensive glutamate marketing is, and should leave you wondering whenever you read an article or watch a program: is it news or is it propaganda?

Linda Bonvie

Even the New Yorker parrots the propaganda of the glutamate industry’s pernicious PR campaign with no regrets
WUI: Writing under the influence
Another MSG YouTube propaganda video
Giving credit where credit is due: Writers engaged in spreading the Glutes’ propaganda and the outlets that enable them
Is this propaganda hiding in the business section of your newspaper?