Aspartame: the placebo used in ‘MSG-is-safe’ studies

But to make sure the conclusion that MSG is harmless would be beyond reproach, glutamate-industry researchers guaranteed that subjects would react to placebos with the same reactions that are caused by MSG. They did that by using aspartame as the toxic ingredient in their placebos, which worked well for them because the aspartic acid in aspartame and the glutamic acid in MSG cause virtually identical reactions (as well as identical brain damage). Having set that up, glutamate-industry researchers (and the propaganda artists who quote them) will say “These people aren’t sensitive to MSG, they reacted to the ‘placebo’ too.”


If you have questions or comments, we’d love to hear from you. If you have hints for others on how to avoid exposure to MfG, send them along, too, and we’ll put them up on Facebook. Or you can reach us at questionsaboutmsg@gmail.com and follow us on Twitter @truthlabeling.

Fraud?

Almost 30 years ago RN’s Rose Chop and Mary Silva writing in the Journal of Professional Nursing noted that “Scientific research typically has been founded on high ethical standards established by researchers in academia and health care research institutions. Scientific fraud, an act of deception or misrepresentation of one’s own work, violates these ethical standards. It can take the form of plagiarism, falsification of data, and irresponsible authorship. Scientific fraud has been attributed to misdirected attempts to attain high levels of personal and professional success. Researchers so prone commit scientific fraud in a search for promotion, status, tenure, and the obtaining of research grants.

With Big Food, we have seen another kind of scientific fraud – one that has nothing to do with attaining high levels of personal and professional success. Research grants are not needed by those who are paid up front to turn out these studies. And there is no need to falsify data as these studies were rigged in advance to produce the numbers that would be needed to draw the conclusions that their sponsor(s) had pre-ordained.

In a 2018 article titled “How do we tackle scientific fraud?” Anne Cooke writing for the British Society for Immunology stated that “fraud or scientific misconduct includes fabrication of data, falsification of data (including data selection and image manipulation), plagiarism (including self-plagiarism and use of other people’s data/ ideas), failure to meet ethical obligations such as obtaining patient consent, misuse of research funds, misrepresentation of data by, for example, not disclosing relevant findings, making inappropriate claims to authorship or failing to include an author who has made a significant contribution.”

Ajinomoto’s program for scientific fraud incorporates little or none of that. They don’t fabricate or falsify data, they simply design studies that will produce the results they are looking for.

If you use only subjects who have never had any reactions known to be caused by MSG, chances are good that the subjects in your study won’t have MSG reactions. If you limit your subjects to people on anti-migraine drugs, chances are that your subjects won’t have migraines. However, those designs aren’t foolproof.

Foolproof

There’s nothing second rate about Ajinomoto’s research. A variety of academics from various universities and medical schools were given study protocols and supervised by Andrew G. Ebert (Ajinomoto’s agent in charge of research) without the involvement of Ajinomoto being disclosed. Although they had common elements, no two studies were identical.

There was, however, one element that was shared by all — the use of excitotoxic amino acids in “placebos.” It’s actually elegant in its simplicity.

In a double-blind study, test material is given to a subject on one occasion, and on another occasion the subject is given a placebo. The placebo, if it’s a true placebo, looks, tastes and smells like the test material, but it will not cause a reaction. If the subject reacts to the inert placebo, the researchers could conclude that the subject is some kind of nut case who might react to anything, and therefore any reactions to MSG test material are coming from what the subject was thinking or imagining, not from the MSG. In industry studies of MSG-safety, subjects were not given true placebos.

That’s it. Simple. By giving subjects alleged placebos that cause the “right” reactions, there may be as many reactions to placebos as there are to MSG test material. From that, researchers could declare they had demonstrated that people really don’t react to MSG. But to make sure the conclusion that MSG is harmless would be beyond reproach, glutamate-industry researchers guaranteed that subjects would react to placebos with the same reactions that are caused by MSG. They did that by using aspartame as the toxic ingredient in their placebos, which worked well for them because the aspartic acid in aspartame and the glutamic acid in MSG cause virtually identical reactions (as well as identical brain damage). Having set that up, glutamate-industry researchers (and the propaganda artists who quote them) will say “These people aren’t sensitive to MSG, they reacted to the ‘placebo’ too.” Case closed!

Resources
FDA Adverse Reactions Monitoring System (ARMS) – Collected Reports of Adverse reactions to monosodium glutamate.

FDA Adverse Reactions Monitoring System (ARMS) – Collected Reports of Adverse reactions to Aspartame.


If you have questions or comments, we’d love to hear from you. If you have hints for others on how to avoid exposure to MfG, send them along, too, and we’ll put them up on Facebook. Or you can reach us at questionsaboutmsg@gmail.com and follow us on Twitter @truthlabeling.

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Without MSG, processed food wouldn’t sell — and there would be no obesity epidemic.

Have you ever stopped to consider that before there was ultra-processed food there was no obesity epidemic? And without MSG there wouldn’t be many, if any, ultra-processed foods on the market.

Flavor-enhancing ingredients aren’t highly visible in processed food, but they’re absolutely essential. Flavor enhancers mask off-flavors, make chemicals taste like food and bring what industry calls an “umami taste” to otherwise bland and unappetizing products.

Those who reap huge profits from the sale of processed foods wouldn’t have a foot in the door without flavor enhancers and won’t be giving them up any time soon. That’s despite the fact that each and every one of them contains excitotoxic (brain damaging) glutamic acid – a.k.a. glutamate.

There are three prerequisites for producing brain damage that will lead to obesity.

First is a brain that is vulnerable to damage due to injury or the immaturity of a fetus or newborn.

Second is sufficient free glutamate — or other potentially excitotoxic material to produce the excesses needed to become excitotoxic. More than enough free glutamate is present in processed foods to accomplish that.

Third, there needs to be a way to deliver this excitotoxic material to a vulnerable brain.

The fetus and newborn have brains that are vulnerable to damage by excitotoxins

In the 1970s it was demonstrated that the brains of newborn animals are vulnerable to glutamate insult. Brain damage, followed by obesity was produced in newborn mice (whose brains, like those of humans, are not fully developed). A student in Dr. John Olney’s lab had observed that mice being used in studies of glutamate-induced retinal dysfunction had become grotesquely obese. A series of studies by Olney and others followed. Many were studies of MSG fed to animals.

Today, there is more than sufficient excitotoxic glutamic acid in ultra-processed food, “fake” food, protein substitutes, and dietary supplements to cause excitotoxicity

When present in amounts needed for normal body function, the neurotransmitter glutamic acid is essential. But when accumulated in amounts greater than the body requires, glutamic acid becomes an excitotoxic neurotransmitter, firing repeatedly and damaging the cells that host targeted glutamate-receptors and/or causing death by over-exciting those glutamate receptors until their host cells die.

Additional confirmation of the brain-damaging effects of excitotoxic free glutamic acid comes from research focused on identifying and understanding human diseases and abnormalities associated with glutamate, often for the purpose of finding drugs that would mitigate glutamate’s adverse effects. By 1980, glutamate-associated disorders such as headaches, asthma, diabetes, muscle pain, atrial fibrillation, ischemia, trauma, seizures, stroke, Alzheimer’s disease, amyotrophic lateral sclerosis (ALS), Huntington’s disease, Parkinson’s disease, depression, multiple sclerosis, schizophrenia, obsessive-compulsive disorder (OCD), epilepsy, addiction, attention-deficit/hyperactivity disorder (ADHD), frontotemporal dementia and autism were on the rise, and evidence of the brain-damaging effects of glutamate were generally accepted by the scientific community.

To become excitotoxic, glutamic acid must be accumulated in considerable quantity. There have always been excitotoxins, although not in food in excessive amounts. But that changed in 1957 when extraction of glutamate from a protein source (which had been a slow and costly method) was replaced by carefully selected genetically modified bacteria that excrete glutamate through their cell walls. That transformation allowed, and still allows, for virtually unlimited production of manufactured free glutamate and MSG.

It wasn’t long before food manufacturers found that profits could be increased by using manufactured free glutamate to produce their own flavor-enhancing additives, and dozens of excitotoxic ingredients were added to the food supply.

Over the next two decades foods containing manufactured/processed free glutamate in ingredients such as hydrolyzed proteins, yeast extracts, maltodextrin, soy protein isolate and MSG flooded the marketplace. And the large amounts of manufactured free glutamate needed to cause excitotoxicity became readily available to anyone consuming multiple processed food products during the course of a day.

Excitotoxins are delivered to the vulnerable brains of fetuses and newborns by their pregnant mothers

Delivery of excitotoxins to the fetus and newborn is easy to understand. Nourishment (and not so nourishing material) is delivered to the fetus in the form of material ingested by a pregnant woman and passed to the fetus through the placenta. A newborn is nourished through its mothers’ milk.

Data from Frieder and Grimm and others confirm that free glutamate can be passed in excessive quantities to neonates and fetuses by expectant mothers who ingest excessive amounts. Glutamate can cross the placenta during pregnancy, can cross the blood brain barrier (BBB) in an unregulated manner during development and can pass through the five circumventricular organs (unique areas of the brain that lie outside the BBB) which are leaky at best at any stage of life. Moreover, the BBB is easily damaged by fever, stroke, trauma to the head, seizures, ingestion of MSG, and the normal process of aging. Similar to drugs and alcohol, free glutamate can also be passed to infants through mothers’ milk.

The obesity epidemic was set in motion as the amount of manufactured free glutamate in processed food, “fake” food, protein substitutes, and dietary supplements became sufficient to wipe out brain cells in the area of the arcuate nucleus of the hypothalamus that would have controlled satiety, appetite, and food intake had they not been obliterated by flavor-enhancers like MSG.


If you have questions or comments, we’d love to hear from you. If you have hints for others on how to avoid exposure to MfG, send them along, too, and we’ll put them up on Facebook. Or you can reach us at questionsaboutmsg@gmail.com and follow us on Twitter @truthlabeling.

Industry’s FDA

It’s no secret that the FDA represents the interests of Big Food and Big Pharma – not consumers. Here is a small example of its allegiance to large corporations that we hadn’t noticed before. Unfortunately, many people still believe that if the FDA says something it must be true.

The following comes from the FDA page called “Questions and Answers on Monosodium glutamate (MSG)” found here: https://www.fda.gov/food/food-additives-petitions/questions-and-answers-monosodium-glutamate-msg accessed on 7/22/2020.

What is MSG?

The FDA says that monosodium glutamate (MSG) is the sodium salt of the common amino acid glutamic acid. Glutamic acid is naturally present in our bodies, and in many foods and food additives.

How is it made?

The FDA says that MSG occurs naturally in many foods, such as tomatoes and cheese. People around the world have eaten glutamate-rich foods throughout history. For example, a historical dish in the Asian community is a glutamate-rich seaweed broth. In 1908, a Japanese professor named Kikunae Ikeda was able to extract glutamate from this broth and determined that glutamate provided the savory taste to the soup. Professor Ikeda then filed a patent to produce MSG and commercial production started the following year.

What is MSG?

Mono (single) sodium glutamate in science-speak is glutamate tied to a sodium ion, just as monopotassium glutamate would be glutamate tied to a potassium ion. That’s the makeup of the mono sodium glutamate occurring naturally in our bodies. (Glutamate is rarely found “free,” but is ordinarily tied to an ion such as sodium or potassium.)

The monosodium glutamate that Ajinomoto is selling is made up of manufactured glutamate, the impurities that invariable accompany manufactured glutamate, and sodium.

How is it made?

MSG doesn’t occur naturally anywhere — it’s made – manufactured! The monosodium glutamate that Ajinomoto is selling is a product made in Ajinomoto’s plant in Eddyville Iowa where glutamate is produced by genetically modified bacteria that secrete glutamate through their cell walls, which is then mixed with sodium. (The process for manufacturing MSG has been patented, and as the process is improved over time new patents are awarded.)

Want to learn more about how the FDA cooperates with industry? You’ll find it on the webpage of the Truth in Labeling Campaign, on Pinterest, in It Wasn’t Alzheimer’s, It Was MSG, in The toxicity/safety of processed free glutamic acid (MSG): A study in suppression of information, and in countless books such as White Wash by Carey Gillam, and Eating May Be Hazardous To Your Health – The Case Against Food Additives by J. Verrett and J. Carper.


If you have questions or comments, we’d love to hear from you. If you have hints for others on how to avoid exposure to MfG, send them along, too, and we’ll put them up on Facebook. Or you can reach us at questionsaboutmsg@gmail.com and follow us on Twitter @truthlabeling.

Tweaking the truth

Psychologists say that if you read, hear or see something often enough, you’ll begin to believe it’s true. Those who manufacture monosodium glutamate (a.k.a. MSG), clearly understand that and have developed cozy relationships (or used other tactics) to influence practically anyone and everyone who has the eyes or ears of consumers. The intent is to promote the message that MSG is a harmless (or even safe) food additive by repeating that mantra over and over again for the public to see, hear, and absorb. Their targets are online “influencers,” those who write for, or are mentioned in, print and internet media, Facebook, Twitter, all other social media outlets, magazines of every description, and, yes, medical journals.

Targets have included celebrity doctors such as Andrew Weil, M.D., respected educational institutions such as Yale, large media outlets like The Washington Post, The New York Times, and the BBC, popular information sources like Food Navigator, and, of course, industry’s lap dog, the FDA.

You probably haven’t noticed all the propaganda being put forth to gain your trust. You’re supposed to absorb it, not notice or analyze it. And those who manage the many glutamate-industry agents who inform you that MSG is harmless or beneficial have successfully worked their con game into a science.

Authors are of all descriptions, some well-known, others not. Some will use assumed names. Some contribute only one article on the harmless nature of MSG, while others like Yvette d’Entremont appear to have a cottage industry going with multiple blogs and podcasts not only about the “safety” of MSG, but about the safety of other toxic substances such as Roundup.

Finding a way to get the word or concept “science” in front of the reader appears to be particularly popular, as if that somehow guarantees that something scientifically proven will be included in the presentation. “Science Friday” and “SciBabe” are two examples.

The following list of writers who have published or endorsed glutamate propaganda is far from complete, but it does represent how far and wide industry has been able to send forth its messaging to the public.

Author, publisher, title of article

Grant Achatz, chef
Interviewed by First We Feast:
“Grant Achatz Doesn’t Go Anywhere Without a Bottle of MSG, and Here’s Why”

Interviewed by msgdish (website of The Glutamate Association):
“Chef Grant Achatz takes MSG to the Test Kitchen”

Donovan Alexander
Appeared in Interesting Engineering:
“MSG makes food taste delicious, but is it actually safe?”

Toby Amidor, MS, RD
Appeared in U.S. News & World Report:
“Scientists have known MSG is safe for decades. Why don’t most Americans?”

Appeared in SHAPE:
“The truth about whether MSG is bad for you”

Quoted in Today’s Dietitian:
“A fresh look at MSG”

Quoted in Food News:
“Why are you still afraid of MSG?”

Elisabeth Anderson
Appeared in Michigan State University Center for Research on Ingredient Safety 101 Series:
“Monosodium Glutamate”

Keith-Thomas Ayoob, EdD, RD, FADA
Appeared in MSGdish (website of The Glutamate Association):
“Serving science about MSG”

Tiffany Ayuda, former senior editor at Prevention and Eat This, Not That
Appeared in Livestrong.com:
“The verdict on MSG: Is it really safe to eat and where is it lurking?”

Anna Maria Barry-Jester, formerly with ABC News and the Center for Public Integrity
Appeared in FiveThirtyEight:
“How MSG got a bad rap: Flawed science and xenophobia”

April Benshosan
Appeared in Livestrong.com:
“Everything you need to know about food ingredients and additives

Michael Blanding
Appeared in Colgate Magazine:
“The strange Case of Dr.Ho Man Kwok”

Heston Blumenthal
Referred to in First We Feast:
“Grant Achatz Doesn’t Go Anywhere Without a Bottle of MSG, and Here’s Why”

Joanna Blythman
Appeared in The Guardian:
“Chinese restaurant syndrome: Has MSG been unfairly demonized?”

Aaron E. Carroll
Appeared in The New York Times:
“Relax, you don’t need to ‘eat clean’”

Lydia Chain
Appeared in ScienceLine:
“MSG: Just some extra umami oomph”

David Chang, American restaurateur, author, television personality, and founder of the Momofuku restaurant group
Referred to in First We Feast:
“Grant Achatz Doesn’t Go Anywhere Without a Bottle of MSG, and Here’s Why”

Appeared on Eater:
“Watch David Chang’s MAD Talk on the Stigma of MSG”

Mary Lee Chin, MS, RD
Appeared in MSGDish (website of The Glutamate Association):
“If MSG is so bad for you, why doesn’t everyone in China have a headache?”
“Breaking down the truth about MSG safety: Is MSG bad for you?”
“YES to cooking at home and answers to “how to use MSG?”


Chin has also contributed to numerous podcasts, articles and blogs providing her “expert” opinion on the “safety” of MSG. She is a consultant to Ajinomoto, Bayer (which acquired Monsanto), and others, specializing in “provocative nutrition topics.”

Stefan Chin, SciShow producer
Video presentation for SciShow:
“The truth about MSG and your health”

On January 28, 2019, the SciShow on YouTube, hosted by Stefan Chin, gave us one of the finest examples of glutamate-industry propaganda seen to date, designed to convince its audience that monosodium glutamate is a harmless food additive. Chin’s recipe for deception is classic.

Bethany Jean Clement, Seattle Times food writer
Appeared in the Seattle Times:
“To MSG or not to MSG? That is the question”

River Davis, Wall Street Journal staff writer
Appeared in the Wall Street Journal:
“Rescuing MSG’s unsavory reputation”

The article headline changed shortly after publication to:
“The FDA says it’s safe, so feel free to say ‘yes’ to MSG”

Signe Dean, ScienceAlert.com managing editor
Appeared in Science Alert:
“This simple video breaks down the real truth about MSG safety, with science”

Carrie Dennett
Appeared in The Seattle Times:
“Avoiding MSG? Look beyond the myths”

Appeared in The Beacon:
“A second look at MSG corrects the record”

Yvette d’Entremont, a.k.a. “SciBabe”
Appeared in Self:
“We all really need to stop freaking out about MSG”
“No more freaking out about MSG”

Caitlin Dewey, specialist in “digital deceptions”
Appeared in The Washington Post:
“Why some Americans avoid MSG even though its ‘health effects’ have been debunked”

Sarah Dickerman
Appeared in Slate:
“Could MSG make a comeback?”

Martin Downs, MPH
Appeared in WebMD:
“The truth about 7 common food additives”

Elizabeth G. Dunn
Appeared in The Wall Street Journal:
“From MSG scare to MVP status: How we learned to love umami”

Yara Elmjoule
Appeared on Facebook and YouTube:
“Stop blaming MSG for your headaches”

Greg Foot, science broadcaster on BBC
Appeared on BBC Earth Lab:
“What is MSG?” (A video presentation)

Sarah Garone, NDTR
Appeared in Today’s Dietician:
“A fresh look at MSG”

Natasha Geiling
Appeared in Smithsonian.com:
“It’s the umami, stupid. Why the truth about MSG is so easy to swallow”

Michael Kerr and Rena Goldman
Appeared in Healthline:
“What is an MSG allergy?”

Amanda Green
Appeared in Decoding Delicious:
“What is MSG, and is it safe to eat?”

Veronique Greenwood
Appeared in BBC Future:
“The man who discovered umami”

Annaliese Griffin, editor, Quartz Daily Obsession
Appeared in Quartz:
“The persistent, racist myth of “Chinese restaurant syndrome” just won’t die”

Marie Haaland
Appeared in SWNS:
“Research finds that close to half of millennials believed these debunked food myths”

Appeared in The New York Post:
“The top ‘food myths’ we have all fallen for”

Bridget Hallinan
Appeared in Food&Wine:
“New Campaign Calls on Merriam-Webster to Redefine ‘Chinese restaurant syndrome’

Tim Hayward
Appeared in Financial Times:
“OMG I love MSG”

Theresa Hedrick, MS, RD
Appeared in MSGdish (website of the Glutamate Association):
“Is MSG Natural? How is MSG made?”
“Is MSG addictive?”

Hannah Hempenstall
Appeared in Better Homes and Gardens:
“Everything you need to know about MSG”

Liz Highleyman
Appeared in MedPage Today:
“Patients often mistake migraine ‘triggers’”

Eddie Huang, actor, restauranteur, chef
Interviewed by NBC News:
“Eddie Huang on racial insensitivities behind MSG, Chinese food criticisms”

Interviewed by Finedininglovers.com:
“Why ‘Chinese restaurant syndrome’ is BS!”

Interviewed by The New York Times:
“The campaign to redefine ‘Chinese restaurant syndrome’”

Interviewed by Vice:
“People are fighting to change an anti-MSG term in the Merriam-Webster dictionary”

Interviewed by HeraldNet, Everett, Washington:
“Asians cringe at ‘Chinese restaurant syndrome’ in dictionary”

Michael Hull
Appeared in Examine.com:
“Is MSG (monosodium glutamate) bad for your health?”

Erin Kelly
Appeared in Thrillist.com:
“Is MSG actually terrible for you?”

Hannah Kerns
Appeared in SheFinds:
“The One Food No One Should Be Eating Anymore In 2020 Because It’s SO Bad For You”

Michael Kerr and Rena Goldman
Appeared in Healthline:
“What is an MSG Allergy?”

Sylvia Klinger, DBA, MS, RD, LDN, CPT
Appeared in MSGdish.com (website of The Glutamate Association):
“Secrets of tasty Latin American cuisine with an umami boost”

Chris Koetke, chef
Appeared in SOUNDBITESRD:
“THE ART & SCIENCE OF MSG & UMAMI”

Appeared in MSGdish (website of The Glutamate Association):
“Do’s and don’ts of using MSG in cooking”

Chris Koetke actively promotes MSG on the MSGdish YouTube Channel. There are 19 links to this article listed on Google.

Becky Krystal, Washington Post food reporter
Appeared in The Washington Post:
“Embrace umami and learn to add its savory goodness to your foods”

Appeared in GoodFood:
“What’s the deal with …umami? (and how to add its savoury goodness to your cooking)”

Sally Kuzemchak, MS, RD
Appeared in WebMD:
“Is MSG really so bad?”

Keng Lam, MD
Appeared in The Berkeley Wellness Letter:
“Is MSG safe?”
“Is MSG (monosodium glutamate) bad for you?”

Abby Langer
Appeared in Chatelaine:
“Everything you think you know about MSG is wrong”

Appeared on Twitter:
“MSG is completely safe”

Elizabeth Laseter, digital editor, Whole Foods Market
Appeared in Allrecipes:
“What is MSG (monosodium glutamate) – and is it safe to eat?”

Joe Leech, MS
Appeared in Healthline:
“MSG (monosodium glutamate): Good or bad?”

John Lehndorff
Appeared in Boulder Weekly:
“Umami: The next level”

Anthea Levi
Appeared in Eat This, Not That!:
“Is MSG actually bad for you?”

Michelle Liang ’23 (A Duke student)
Appeared in DukeArts:
“From MSG to COVID-19: The politics of America’s fear of Chinese food”

Kevin Loria
Appeared in Business Insider:
“Is MSG sodium in Chinese food safe to eat?”

Claire Lower
Appeared in Lifehacker Skillet:
“Put MSG in everything, you cowards”

Fiona Lu, University of Chicago Booth School of Business undergraduate student
Appeared in UChicago Bite:
“Demystifying MSG”

Gus Lubin
Appeared in Business Insider:
“Everyone should cook with MSG, says food scientist”

Hillary Maglin, Travel + Leisure Magazine assistant editor
Appeared in Rachael Ray Every Day:
“Surprise: MSG has been completely safe to eat all this time”

John Mahoney
Appeared in Buzzfeed:
“The notorious MSG’s unlikely formula for success”

Jeannie Mai, TV host and celebrity stylist
Appeared in adweek.com:
“Celebrities Want to Redefine ‘Chinese Restaurant Syndrome’”

Appeared in arkansasonline.com:
“Bid starts to redefine ‘Chinese restaurant syndrome’”

Appeared in NBC News:
“Eddie Huang on racial insensitivities behind MSG, Chinese food criticisms”

Appeared in adage.com:
“MSG maker starts campaign aimed at debunking ‘Chinese restaurant syndrome”

Appeared in Federal News Network:
“Merriam-Webster revises ‘Chinese restaurant syndrome’ entry”

Appeared in Food&Wine:
“New Campaign Calls on Merriam-Webster to Redefine ‘Chinese restaurant syndrome’”

Appeared in ABC News:
“Asians cringe at ‘Chinese restaurant syndrome’ in dictionary”

Appeared in ABC News:
“Merriam-Webster revises ‘Chinese restaurant syndrome’”

Appeared in bbc.com:
“’Chinese Restaurant Syndrome’ – what is it and is it racist?”

These articles feature Jeannie Mai’s participation in the Ajinomoto campaign dubbed “Redefine CRS.”

Darwin Malicdem
Appeared in Medical Daily:
“Does MSG have negative effect on brain health?”

Denise Mann, MS
Appeared in The Healthy:
“What is MSG – and how bad is it, really?”

Selvi Megawati
Appeared in We Think We Share:
“Umami: The fifth taste after eating foods that contain MSG”

Chris Mohr, PHD, RD, “nutrition expert”
Appeared in Men’s Health:
“Is MSG bad for you? No – and here’s why.”

Carla Lalli Music, Bon Appetit food director
Appeared in Bon Appetit and Yahoo! News:
“Give MSG a chance – really”

Interviewed for Salon:
“BonAp food boss Carla Lalli-Music: Not only is MSG okay, it is a core staple in the pantry”

Myupchar
Appeared in Firstpost:
“Monosodium Glutamate (MSG) in your food: Is it really as bad as some experts claim?”

Jill Neimark
Appeared in BrainFacts:
“Umami: The fifth taste”

Amelia Nierenberg, NYT reporter on the “Food Desk”
Appeared in The New York Times and The World News:
“The campaign to redefine ‘Chinese Restaurant syndrome’”

Bianca Nogrady
Appeared in BBC Future:
“Is MSG as bad as it’s made out to be?”

Karen Palmer
Appeared in Tasting Table:
“OMG MSG Great chefs love the umami-rich powder, and so should you”

Tia Rains, Ajinomoto Co. Inc., senior director, public relations
Appeared in Sound Bites:
“The art and science of MSG & Umami”

Appeared in Ajinomoto, Eat Well Live Well:
“Busting nutrition myths: Tia Rains built her career correcting misconceptions around food”

Tia Rains is heading up Ajinomoto’s US $10-million, three-year PR blitz.

Ryan Raman, MS, RD
Appeared in EcoWatch (via Healthline):
“Does MSG cause headaches?”

Michele Redmond, MS, RDN
Appeared in Food & Nutrition (also republished in MSGDish (website of the glutamate association):
“Make low-salt cooking taste amazing with an umami boost”

Monica Reinagel, MS, LDN
Appeared in MyFitnessPal:
“Is MSG safe?”

Alex Renton
Appeared in The Guardian:
“If MSG is so bad for you, why doesn’t everyone in Asia have a headache?”

Helen Rosner, roving food correspondent for The New Yorker
Appeared in The New Yorker:
“An MSG convert visits the high church of umami”

“Last month, on a visit to Tokyo, I spent a morning paying my respects at the altar of umami, … the production headquarters of Ajinomoto…”

Joanna Rothkopf, writer, actress
Appeared in Esquire:
“It’s time for America to fall back in love with MSG”

This was one of the numerous articles authored by attendees of the World Umami Forum, put together by Ajinomoto in September 2018.

Jackson Ryan
Appeared in Lifehacker.com:
“Is MSG Really That Bad For You?”

Atsuko Sasaki
Appeared in the Academy of Nutrition and Dietetics, Eat Right:
“Umami. The science and lore of healthy eating”

Ruth Schuster
Appeared in Harretz:
“MSG-spiked Soup Helps Make Better Food Choices, Says Report”

Kavin Senapathy, SciMom

Senapathy is co-author of a book, “The Fear Babe: Shattering Vani Hari’s Glass House,” published in October 2015 by Senapath Press. The book promotes genetically engineered foods, claims aspartame and MSG are safe, and purports to explain the “facts behind those toxic pesticide scares.”

Abbey Sharp, in sponsored partnership with Ajinomoto
Appeared in Abbey’s Kitchen:
“MSG effects and claims debunked – Does MSG cause headaches?”

Alexandra Sifferlin
Appeared in Time:
“Eat umami, eat less”

Beth Skwarecki
Appeared in Lifehacker:
“Stop being afraid of MSG”

Elizabeth Somer, MA, RD
Appeared in WebMD:
“Does Chinese food give you a headache?”

Mary Ellen Shoup
Appeared in FoodNavigator-USA.com:
“Study looks at reducing sodium intake through MSG substitution in saltiest food categories”

T.L. Stanley
Appeared in AdWeek:
“The Company Behind MSG Urges Merriam-Webster to Drop ‘Chinese Restaurant Syndrome’”

Mark Stock, writer, wine expert
Appeared in The Manual:
“What is MSG why do we argue about it?”

Terry Tang
Appeared in the Arkansas Democrat Gazette:
“Bid starts to redefine ‘Chinese restaurant syndrome’”

Appeared in AP News:
“Asians cringe at ‘Chinese restaurant syndrome’ in dictionary”

Kaye Taylor, MS
Appeared in MSGdish (website of The Glutamate Association):
“Here’s the lowdown: How MSG makes foods taste better”
“Treat your family to a picnic with savory picnic salads”
“It’s spring: Time to lighten up serious food talk!”
“8 tips for using MSG in cooking and in recipes”

Carlene Thomas, RDN
Appeared in OhCarlene healthfullyeverafter.co:
“Is MSG safe? Umami 101: Everything you want to know about MSG safety, health and the facts”

Amy Toffelmire
Appeared in medbroadcast.com:
“MSG: Is monosodium glutamate safe?”

Archit Tripathi
Appeared in didyouknowfacts.com:
“Is MSG really a toxic food?”

Chau Tu, Slate Plus associate editor
Appeared in The World:
“Science suggests MSG really isn’t bad for your health after all”

Appeared in Science Friday:
“Is MSG bad for your health?”

Robin Tucker, Michigan State University assistant professor of food science and human nutrition
Interviewed by PBS station WKAR “Serving up science”:
“Umami: The most complex taste

Dr. Taylor Wallace, self-described as “America’s favorite food scientist”
Appeared in drtaylorwallace.com:
“Sensitive to MSG? Guess what…you’re not!”

Karla Walsh
Appeared in Better Homes & Gardens:
“Yes, MSG is safe to eat, plus everything else to know about the flavor enhancer”

Andrew Weil, M.D.
Appeared in drweil.com:
“How safe is MSG?”

Corey Williams
Appeared in Yahoo! Life:
“What is umami and what does it taste like?”

Marguerite Winter
Appeared in Financial Review:
“So much more to umami than taste”

Dr. Steve Witherly, “food scientist”
Interviewed by Business Insider:
“Everyone should cook with MSG, says food scientist”

Sam Wong, New Scientist digital reporter
Appeared in NewScientist:
“Umami: How to maximise the savoury taste that makes food so satisfying”

Renee Wu
Appeared in Yale Scientific:
“Is MSG bad for you?”

Judith Wurtman, Ph.D.
Appeared in Psychology Today:
“Monosodium Glutamate: Will It Make Us Eat More or Less?”

Connie Xu
Appeared in Spoonuniversity.com:
“Everything you need to know about MSG”

Kimmy Yam
Appeared in NBC News:
“Eddie Huang on racial insensitivities behind MSG, Chinese food criticisms”

Jessie Yeung, CNN Digital Worldwide digital producer
Appeared in CNN:
“MSG in Chinese food isn’t unhealthy – you’re just racist, activists say”

Althea Zanecosky, MS, RD, LDN
Appeared in MSGdish (website of The Glutamate Association):
“Good taste. Bad taste. No taste.”
“Stop the food label fear-mongering”

Katherine Zeratsky, R.D., L.D.
Appeared in Mayoclinic.org:
“What is MSG? Is it bad for you?”

Publications with no author listed

Appeared in the Associated Press:
“Merriam-Webster revises ‘Chinese restaurant syndrome’ entry”

Appeared in New York Times Ad Age:
“MSG Maker starts campaign aimed at debunking ‘Chinese Restaurant Syndrome’”

Appeared in Independent Newspapers Limited (Nigeria):
”WASCO Sensitises Media On Safety Of Ajinomoto”

Appeared in Unilever Food Solutions:
“Myths and Facts on MSG” (Chef training and resources)

Participants in the World Umami Forum, September 2018

EVENT HOST
Andrew Zimmern, Master of Ceremonies
Celebrity Chef & TV Personality

PRESENTERS
Gary K. Beauchamp, PhD, Distinguished Member, Emeritus Director and President, Monell Chemical Senses Center

(Beauchamp has been turning out studies for Ajinomoto at Monell since 1968.)

Ali Bouzari, PhD Chief Science Officer, Pilot R&D

Chris Koetke, Chef, CEO, Complete Culinary, LLC

Sarah Lohman, Historic Gastronomist & Author

Kumiko Ninomiya, PhD, Director, Umami Information Center, Executive Fellow, Ajinomoto Co., Inc.

Jordan Sand, PhD, Professor of Japanese History and Culture, Georgetown University
(Sand wrote a very nice history of MSG. Interesting to note that there was no mention that some people found it toxic.)

Nadia Berenstein, PhD, Food Historian & Writer

Lisa Watson, MS, Senior Science Advisor, MS, The Glutamate Association

PANELISTS
Harold McGee, Food Science Write

Dan Pashman, Host, The Sporkful Podcast

Mary Lee Chin, MS, RD, Health Communicator, Nutrition Edge Communications

Jason Riis, PhD, Senior Research Fellow, Wharton School, University of Pennsylvania

Tia M. Rains, PhD, Senior Director of Public Relations, Ajinomoto Health & Nutrition North America, Inc

Infertility? You could blame it on your mother – but there really was no way for her to have known.

According to the American Pregnancy Association, there are three main causes of infertility in males: a hypothalamic or pituitary disorder (1-2%), gonad disorder (30-40%), and sperm transport disorder (10-20%). That leaves 40-50% of cases with unknown causes.

None of these, however, is a root cause of infertility. They are names of categories of disorders that define infertility. Infertility may be traced back to a hypothalamic or pituitary disorder, for example, but the question remains –what caused those disorders to begin with?

Science combined with simple logic focused on problem solving says that hypothalamic, pituitary, gonad and sperm transport disorders are caused by damage done to the vulnerable, developing brains of fetuses and infants by brain-damaging chemicals, delivered by pregnant and lactating women.

1) Brain damage, followed by reproductive disorders, can be produced in human fetuses and newborns whose brains are not fully developed.

2) Excitotoxic amino acids (glutamic acid and aspartic acid) will cause brain damage when delivered in quantity to developing, vulnerable brains.

3) Brain-damaging amino acids consumed by pregnant and lactating women will be passed to their fetus through the placenta and to infants through mother’s milk.

4) Excitotoxic amino acids are readily available in processed and ultra-processed foods, protein powders and protein drinks, protein substitutes, flavor enhancers, pharmaceuticals, dietary supplements, cosmetics, and vaccine excipients.

Here’s how it works

A study demonstrating glutamate-induced brain damage was published in Science by John Olney, M.D. way back in 1969, titled “Brain lesions, obesity, and other disturbances in mice treated with monosodium glutamate.” Olney established that:

1) Brain damage, followed by reproductive disorders, can be produced in newborn mice, whose brains are not fully developed. A student in Olney’s lab had observed that mice being used in studies of glutamate-induced retinal dysfunction had become grotesquely obese. A series of studies by Olney and others followed. Many of them were studies of MSG fed to animals.

2) Excitotoxic amino acids (glutamic acid and aspartic acid) will cause brain damage when delivered in quantity to the vulnerable brains of neonatal mice.

When present in amounts needed for normal body function, glutamic acid is essential. But when accumulated in amounts greater than that needed for normal body function, the neurotransmitter glutamic acid becomes an excitotoxic neurotransmitter, firing repeatedly, damaging the cells that host targeted glutamate-receptors and/or causing death by over-exciting those glutamate receptors until their host cells die.

3) Excitotoxic amino acids can be delivered to neonatal mice through feeding.

In the laboratory, researchers manipulated dosage of glutamic acid and aspartic acid until they found those that were lethal to brain cells.

Additional confirmation of the brain-damaging effects of excitotoxic free glutamic acid comes from research focused on identifying and understanding human diseases and abnormalities associated with glutamate, often for the purpose of finding drugs that would mitigate glutamate’s adverse effects. By 1980, glutamate-associated disorders such as headaches, asthma, diabetes, muscle pain, atrial fibrillation, ischemia, trauma, seizures, stroke, Alzheimer’s disease, amyotrophic lateral sclerosis (ALS), Huntington’s disease, Parkinson’s disease, depression, multiple sclerosis, schizophrenia, obsessive-compulsive disorder (OCD), epilepsy, addiction, attention-deficit/hyperactivity disorder (ADHD), frontotemporal dementia and autism were on the rise, and evidence of the brain-damaging effects of glutamate were generally accepted by the scientific community.

Having provided evidence that brain lesions can be induced in fetuses and neonates thru the introduction of excitotoxins, and having pointed out that glutamic acid is an excitotoxin, the only question that remains is how excitotoxic glutamic acid could get to the vulnerable brain of the infant or the fetus causing brain damage, destroying those areas of the arcuate nucleus that would regulate reproductive function had they not been obliterated.

To be excitotoxic, glutamic acid has to be accumulated in considerable quantity. There have always been excitotoxins, although not in food in excessive amounts. But that changed in 1957 when there was a transformation in the method of producing the glutamate used in MSG from extraction of glutamate from a protein source, which had been a slow and costly method, to using carefully selected genetically modified bacteria to excrete glutamate through their cell walls. That allowed virtually unlimited production of manufactured free glutamate and MSG.

It wasn’t long before food manufacturers found that profits could be increased by using manufactured free glutamate to produce their own flavor-enhancing additives, and dozens of excitotoxic ingredients were added to the food supply. Over the next two decades, the marketplace became flooded with manufactured/processed free glutamate in ingredients such as hydrolyzed proteins, yeast extracts, maltodextrin, soy protein isolate and MSG — and the large amounts of manufactured free glutamate needed to cause excitotoxicity became readily available to anyone consuming a number of processed food products during the course of a day.

Today, there is more than sufficient excitotoxic glutamic acid in food, “fake” food and dietary supplements to cause excitotoxicity.

Once it is understood that excitotoxins are readily available, transport to fetus and newborn becomes easy to understand. Nourishment (and not so nourishing material) is delivered to the fetus in the form of material ingested by a pregnant woman and passed to the fetus through the placenta.

Data confirm that free glutamate can be passed in excessive quantities to neonates and fetuses by expectant mothers who ingest excessive amounts. Glutamate can cross the placenta during pregnancy, can cross the blood brain barrier (BBB) in an unregulated manner during development and can pass through the five circumventricular organs (unique areas of the brain that lie outside the BBB) which are leaky at best at any stage of life. Moreover, the BBB is easily damaged by fever, stroke, trauma to the head, seizures, ingestion of MSG, and the normal process of aging. Similar to drugs and alcohol, free glutamate can also be passed to infants through mothers’ milk.

But a crisis? All of a sudden?

There has always been infertility, but not in such numbers that it could be called a crisis. There have always been amino acids that could become excitotoxic, but not to the extent that they could accumulate and become excitotoxic. The infertility crisis began after amino acids with excitotoxic potential became available in the quantity necessary to cause them to become excitotoxic – made possible by the 1957 introduction of monosodium glutamate produced by bacterial fermentation.

Science combined with a good dose of logic tell us that glutamic acid passed to fetus and neonate by pregnant and lactating women is the root cause of the infertility crisis.


If you have questions or comments, we’d love to hear from you. If you have hints for others on how to avoid exposure to MfG, send them along, too, and we’ll put them up on Facebook. Or you can reach us at questionsaboutmsg@gmail.com and follow us on Twitter @truthlabeling.

Resources

American Pregnancy Association https://americanpregnancy.org/getting-pregnant/male-infertility/

Olney JW. Brain lesions, obesity, and other disturbances in mice treated with monosodium glutamate. Science. 1969;164(880):719-721.

Olney JW. Glutamate-induced neuronal necrosis in the infant mouse hypothalamus. J Neuropathol Exp Neurol. 1971;30(1):75-90.

Burde RM, Schainker B, Kayes J. Acute effect of oral and subcutaneous administration of monosodium glutamate on the arcuate nucleus of the hypothalamus in mice and rats. Nature. 1971;233(5314):58-60.

Olney JW, Sharpe LG, Feigin RD. Glutamate-induced brain damage in infant primates. J Neuropathol Exp Neurol. 1972;31(3):464-488.

Burde RM, Schainker B, Kayes J. Monosodium glutamate: necrosis of hypothalamic neurons in infant rats and mice following either oral or subcutaneous administration. J Neuropathol Exp Neurol. 1972;31(1):181.

Olney JW, Rhee V, DeGubareff T. Neurotoxic effects of glutamate on mouse area postrema. Brain Res. 1977;120(1):151-157.

Olney JW, Ho OL. Brain damage in infant mice following oral intake of glutamate, aspartate or cystine. Nature. 1970;227:609-611.

Lemkey-Johnston N, Reynolds WA. Nature and extent of brain lesions in mice related to ingestion of monosodium glutamate: a light and electron microscope study. J Neuropath Exp Neurol. 1974;33(1):74-97.

Takasaki, Y. Protective effect of mono- and disaccharides on glutamate-induced brain damage in mice. Toxicol Lett. 1979;4(3): 205-210.

Takasaki, Y. Protective effect of arginine, leucine, and preinjection of insulin on glutamate neurotoxicity in mice. Toxicol Lett. 1980;5(1):39-44.

Lemkey-Johnston, N, Reynolds WA. Nature and extent of brain lesions in mice related to ingestion of monosodium glutamate: a light and electron microscope study. J Neuropath Exp Neurol. 1974;33(1):74-97.

Bahadoran Z, Mirmiran P, Ghasemi A. Monosodium Glutamate (MSG)-Induced Animal Model of Type 2 Diabetes. Methods Mol Biol. 2019;1916:49-65.

Sharma A. Monosodium glutamate-induced oxidative kidney damage and possible mechanisms: a mini-review. J Biomed Sci. 2015;22:22:93.

Kurose T, Sugano E, Sugai A, Shiraiwa R, Kato M, Mitsuguchi Y, Takai Y, Tabata K, Honma Y, Tomita H. Neuroprotective effect of a dietary supplement against glutamate-induced excitotoxicity in retina. Int J Ophthalmol. 2019;12(8):1231-1237.

Moneret-Vautrin DA. Monosodium glutamate-induced asthma: study of the potential risk of 30 asthmatics and review of the literature. Allerg Immunol (Paris). 987;19(1):29-35.
Olloquequi J, Cornejo-Córdova E, Verdaguer E, Soriano FX, Binvignat O, Auladell C, Camins A. Excitotoxicity in the pathogenesis of neurological and psychiatric disorders: Therapeutic implications. J Psychopharmacol. 2018;32(3):265-275.

Binvignat O, Olloquequi J. Excitotoxicity as a Target against Neurodegenerative Processes. Curr Pharm Des. 2020 Jan 13. doi:10.2174/1381612826666200113162641.

Hashimoto S. Discovery and History of Amino Acid Fermentation.
Adv Biochem Eng Biotechnol. 2017;159:15-34.

Sano C. History of glutamate production. Am J Clin Nutr. 2009;90(3):728S-732S.

Frieder B, Grimm VE. Prenatal monosodium glutamate (MSG) treatment given through the mother’s diet causes behavioral deficits in rat offspring. Intern J Neurosci. 1984;23(2):117-126.

Gao J, Wu J, Zhao XN, Zhang WN, Zhang YY, Zhang ZX. [Transplacental neurotoxic effects of monosodium glutamate on structures and functions of specific brain areas of filial mice.] Sheng Li Hsueh Pao Acta Physiologica Sinica. 1994;46(1):44-51.

Yu T, Zhao Y, Shi W, Ma R, Yu L. Effects of maternal oral administration of monosodium glutamate at a late stage of pregnancy on developing mouse fetal brain. Brain Res. 1997;747(2):195-206.

Arya V, Demarco VG, Issar M, Hochhaus G. Contrary to adult, neonatal rats show pronounced brain uptake of corticosteroids.
Drug Metab Dispos. 2006;34(6):939-42.

Moretti R, Pansiot J, Bettati D, Strazielle N, Ghersi-Egea JF, Damante G, Fleiss B, Titomanlio L, Gressens P. Blood-brain barrier dysfunction in disorders of the developing brain. Front Neurosci. 2015 Feb 17;9:40.

Price MT, Olney JW, Lowry OH, Buchsbaum S. Uptake of exogenous glutamate and aspartate by circumventricular organs but not other regions of brain. J Neurochem. 1981;36(5):1774-1780.

Skultetyova I, Tokarev D, Jezova D. Stress-induced increase in blood-brain barrier permeability in control and monosodium glutamate-treated rats. Brain Res Bull. 1998;45(2):175-178.

Broadwell RD, Sofroniew MV. Serum proteins bypass the blood-brain fluid barriers for extracellular entry to the central nervous system. Exp Neurol. 1993;120(2):245-263.

Blaylock RL. Excitotoxins: The Taste That Kills. Santa Fe, New Mexico: Health Press; 1994.

Nemeroff CB, Crisley FD. Monosodium L-glutamate induced convulsions: temporary alteration in blood-brain barrier permeability to plasma proteins. Environ Physiol Biochem. 1975;5(6):389-395.

Brown RA, Dakkak H, Seabrook JA. Is Breast Best? Examining the effects of alcohol and cannabis use during lactation. J Neonatal Perinatal Med. 2018;11(4):345-356.

CAUTION!

Are the plant-based diets you’re thinking about eating made with plants or in plants?

Don’t be taken in by the con artists whose “plant based” products are made out of chemicals in chemical factories with virtually nothing added that’s grown in water or in the ground.


If you have questions or comments, we’d love to hear from you. If you have hints for others on how to avoid exposure to MfG, send them along, too, and we’ll put them up on Facebook. Or you can reach us at questionsaboutmsg@gmail.com and follow us on Twitter @truthlabeling.

The art of hiding MfG

Artists don’t just paint, sing, play an instrument or act. Some of the best artists out there utilize their talents to deceive you.

At the Truth in Labeling Campaign we’ve run into many great artists working in public relations firms. They understand human nature and can paint word pictures to sell you almost anything.

We’ve met men and women who have elevated lying to an art form. And rarely do their targets know that they’re being deceived. Then there are the marketing people who often employ a variety of specialized artists to push their products.

Some who hide manufactured free glutamate (MfG), the toxic ingredient in MSG, do it cleverly but not creatively. They use distraction to draw your focus away from the dangers of their product, talking about the benefits of low salt, muscle building, or the umami flavor. And they’ll very likely use ingredients that you’re not going to recognize as containing MfG.

Ingredients called “glutamic acid” and “disodium inosinate” are prime examples. You’ll find them in flavor enhancers like Braggs Aminos and soups and bouillon like Minor’s soup bases.

Not to be overlooked are those who sell products containing MfG to bakeries and restaurants claiming that their products are free of MSG, and the bakeries and restaurants that use those products as though they contained no MfG. Those businesses don’t routinely display the names of ingredients used in their products, and some are proud to make the misleading claim that they don’t use MSG (the name that most consumers give to all ingredients that contain MfG). That’s not even artful lying. It’s just a subterfuge.




If you have questions or comments, we’d love to hear from you. If you have hints for others on how to avoid exposure to MfG, send them along, too, and we’ll put them up on Facebook. Or you can reach us at questionsaboutmsg@gmail.com and follow us on Twitter @truthlabeling.