Excitotoxins in processed food: The best guarded secret of the food and drug industries

Excitotoxicity is the pathological process by which nerve cells are damaged or killed by excessive stimulation by neurotransmitters such as glutamic acid (glutamate).

In 1969 when researcher Dr. John Olney of Washington University in St. Louis observed that process in his laboratory, it should have resulted in sweeping changes in how food additives are regulated. 

He noted that glutamate fed as monosodium glutamate (MSG) to laboratory animals killed brain cells and subsequently caused gross obesity, reproductive dysfunction, and behavior abnormalities.

Before that, the world knew nothing of what Dr. Olney had dubbed “excitotoxins.” And after Olney’s discovery, the existence of free excitotoxic amino acids present in food became the best-guarded secret of the food and drug industries.

Today, excitotoxins present in food remain largely ignored or unknown, mostly because the rich and powerful food and pharmaceutical industries want it that way. A great deal of food industry profit depends on using excitotoxins to “enhance” the taste of cheaply made food. And a great deal of pharmaceutical industry profit depends on selling drugs to “cure” the diseases and disabilities caused by the excitotoxins in the food supply.

What are excitotoxins?

Excitotoxins are often amino acids, but not all amino acids are excitotoxins. The amino acid with the greatest excitotoxic footprint is glutamate. When present in protein or released from protein in a regulated fashion (through routine digestion), glutamate is vital to normal body function. It is the major neurotransmitter in humans, carrying nerve impulses from glutamate stimuli to glutamate receptors throughout the body. Yet, when present outside of protein in amounts that exceed what the healthy human body was designed to accommodate (which can vary widely from person to person), glutamate becomes an excitotoxic neurotransmitter, firing repeatedly, damaging targeted glutamate-receptors and/or causing neuronal and non-neuronal death by over exciting those glutamate receptors until their host cells die.

Technically speaking, neurotransmitters that over-stimulate their receptors to the point of killing the cells that host them are called excitotoxic neurotransmitters, and the resulting condition is referred to as excitotoxicity. Glutamate excitotoxicity is the process that underlies the damage done by MSG and the other ingredients that contain processed free glutamic acid (MfG). 

Glutamate is called a non-essential amino acid because if the body does not have sufficient quantities to function normally, any needed glutamate can be produced from other amino acids. So, there is no need to add glutamate to the human diet. The excitotoxins in MSG and other ingredients that contain MfG are not needed for nutritional purposes. MSG and many other ingredients have been designed to enhance the taste of cheaply made food for the sole purpose of lining the pockets of those who manufacture and sell them.

Glutamate neurotransmitters trigger glutamate receptors both in the central nervous system and in peripheral tissue (heart, lungs, and intestines, for example). After stimulating glutamate receptors, glutamate neurotransmitters may do no damage and simply fade away, so to speak, or they may damage the cells that their receptors cling to, or overexcite their receptors until the cells that host them die.

There’s another possibility. There are a great many glutamate receptors in the brain, so it’s possible that if a few are damaged or wiped out following ingestion of MfG, their loss may not be noticed because there are so many undamaged ones remaining. It is also possible that individuals differ in the numbers of glutamate receptors that they have. If so, people with more glutamate receptors to begin with are less likely to feel the effects of brain damage following ingestion of MfG because even after some cells are killed or damaged, there will still be sufficient numbers of undamaged cells to carry out normal body functions.

That might account for the fact that some people are more sensitive to MfG than others.

Less is known about glutamate receptors outside the brain – in the heart, stomach, and lungs, for example. It would make sense (although that doesn’t make it true) that cells serving a particular function would be grouped together. It would also seem logical that in each location there would be fewer glutamate receptors siting on host cells than found in the brain, and for some individuals there might be so few cells with glutamate receptors to begin with, that ingestion of even small amounts of MfG might trigger asthma, atrial fibrillation, or irritable bowel disease; while persons with more cells hosting glutamate receptors would not notice damage or loss.

Short-term effects of excitotoxic glutamate (such as asthma and migraine headache) have long been obvious to those not influenced by the rhetoric of the glutamate industry and their friends at the U.S. Food and Drug Administration. Hopefully, researchers will soon begin to correlate the adverse effects of glutamate ingestion with endocrine disturbances such as reproductive disorders and gross obesity. It is well known that glutamate plays an important role in some mental disorders and neurodegenerative diseases, but the fact that ingestion of excitotoxic glutamate might contribute to existing pools of free glutamate that could become excitotoxic, still needs to be considered. Finally, a few have begun to realize the importance of glutamate’s access to the human body through the mouth, nose and skin.

There are three excitotoxic amino acids used in quantity in food, cosmetics, pharmaceuticals, protein drinks and powders, and dietary supplements:

1) Glutamic acid — found in flavor enhancers, infant formula, enteral care products for invalids, protein powders, processed foods, anything that is hydrolyzed, and some pesticides/fertilizers.

2) Aspartic acid — found in low-calorie sweeteners, aspartame and its aliases, infant formula, protein powders, anything that is hydrolyzed, and

3) L-cysteine — found in dough conditioners.

According to Dr. Edward Group, the six most dangerous excitotoxins are: MSG (monosodium glutamate), aspartate, domoic acid, L-BOAA, cysteine, and casein.

If you have questions or comments, we’d love to hear from you.  And if you have hints for others on how to avoid exposure to MfG, send them along, too, we’ll put them up on Facebook.  You can also reach us at questionsaboutmsg@gmail.com and follow us on Twitter @truthlabeling

Resources

Dr. Edward Group The 6 Most Dangerous Excitotoxins. Global Healing Center.  (accessed 8/20/2016)

Blaylock RL. Excitotoxins: The Taste That Kills. Santa Fe, New Mexico: Health Press; 1994.

Olney JW. Brain Lesions, Obesity, and Other Disturbances in Mice Treated with Monosodium Glutamate; Science. 1969;164:719-21.  

Olney JW, Ho OL. Brain damage in infant mice following oral intake of glutamate, aspartate or cystine. Nature. 1970;227:609-611.

Olney, J.W. Excitatory neurotoxins as food additives: an evaluation of risk. Neurotoxicology 2: 163-192, 1980.

Olney JW. Excitotoxins in foods. Neurotoxicology. 1994 Fall;15(3):535-44.

Gudiño-Cabrera G, Ureña-Guerrero ME, Rivera-Cervantes MC, Feria-Velasco AI, Beas-Zárate C. Excitotoxicity triggered by neonatal monosodium glutamate treatment and blood-brain barrier function. Arch Med Res. 2014 Nov;45(8):653-9.

Verywellhealth.com.  An Overview of Cell Receptors and How They Work https://www.verywellhealth.com/what-is-a-receptor-on-a-cell-562554   (Accessed 5/5/2019)

‘Likely culprit’ in celiac disease hidden in processed foods

Why is Ajinomoto trying so hard to keep transglutaminase unlabeled?

Over the past few decades celiac disease (CD) has morphed into a “major public health problem.” Along with it, other autoimmune conditions such as diabetes, rheumatoid arthritis, inflammatory bowel disease and psoriasis, are also topping the charts as very common disorders with dozens of heavily advertised drugs created to treat them.

If you ask why, the knee-jerk response is typically that better testing has uncovered all these otherwise undisclosed conditions. But does that really explain things? And it certainly doesn’t take into consideration what experts refer to as large numbers of people with undiagnosed autoimmune diseases, especially CD.

Back in 2015 two researchers with expertise in metabolic diseases, Aaron Lerner, a professor at Tel Aviv University, and Torsten Matthias, affiliated with the AESKU.KIPP Institute in Germany, first sounded the alarm on a largely unknown, widely used food additive – an enzyme called transglutaminase (TG). At that time, they proposed a “hypothesis” linking TG used in food processing to celiac and other autoimmune diseases. Four years later, however, the pair stated that further research and observations have closed the “gaps” in our understanding of how TG is an “inducer of celiac disease.”   

Big Food’s favorite find to ‘glue’ things together

Transglutaminase, a.k.a. “meat glue,” is the darling of Big Food for lots of reasons: it can glue together scraps of fish, chicken and meat into whole-looking cuts (often called “Frankenmeats”); extend the shelf life of processed foods (even pasta); improve “texture,” especially in low-salt, low-fat products; make breads and pastries (particularly gluten-free ones) rise better, and, as one manufacturer puts it, allow for use of things that would ordinarily be tossed out — unappetizing leftovers and scraps of food that would “otherwise be considered waste ingredients, creating an added-value product.”

But more than just turning “waste ingredients” into new food products, there are a host of other reasons why you should do your best to steer clear of meat glue.

‘Tight junction dysfunction’

The 2015 research published by Lerner and Matthias detailed how certain food additives may be behind the steady rise of autoimmune diseases due to something called “tight junction dysfunctions,” which can set the stage for a wide variety of serious ailments, calling out transglutaminase as one of the commonly used food additives that can enhance “intestinal junction leakage.”

A subsequent study in 2019 recognized transglutaminase as a “likely culprit” in celiac disease.

In 2020, Lerner and Matthias published yet another paper on transglutaminase and celiac disease, calling it a “potential public health concern” and saying that they hope their review will “encourage clinical, scientific and regulatory debates on (its) safety to protect the public.”

Despite all the warnings and additional research, use of the enzyme is booming, and all its food uses are now considered GRAS (generally recognized as safe) by the FDA.

TG and MSG

The similarities between MSG and transglutaminase are quite noteworthy. Not only is the enzyme manufactured in great quantities by Ajinomoto (as is MSG) but the way TG is promoted by the company is remarkably similar to its long-running propaganda campaign claiming that MSG is a safe ingredient.

For example, Ajinomoto states on its websites and elsewhere that both MSG and TG are “found in food naturally,” are “safe,” used in many countries and considered GRAS in the U.S. by the FDA. And just as MSG supposedly in no way causes serious reactions, the company says that TG in no way causes celiac disease – in fact, under some circumstances the TG added to food can actually help CD patients, Ajinomoto says.

While transglutaminase is found naturally in the human body (as is glutamate), there is a significant difference between microbial TG (the manufactured additive) and “our own transglutaminase” says Lerner.  (Just as there is a major difference between manufactured MSG and the glutamate in your body).

That’s because the tissue TG produced in the body “has a different structure (from) the microbial sort, which allows its activity to be tightly controlled. Microbial transglutaminase itself could also increase intestinal permeability,” he says, “by directly modifying proteins that hold together the intestinal barrier.”

The FDA has “no questions”

While once the FDA pretended to look into the safety of a product before granting it GRAS status, not even that is done any more.  Now a company simply turns in a statement that a product should be referred to as GRAS, and it’s done.

Starting in 1998 Ajinomoto filed four notices of “self-determined” GRAS status for TG with the FDA. The first was to use TG in seafood. In 1999 they sent in more intended uses for hard and soft cheeses, yogurt, and “vegetable protein dishes/veggie burgers/meat substitutes.” In 2000 Ajinomoto sent another notice to the FDA regarding using transglutaminase in pasta, bread, pastries, ready-to-eat cereal, pizza dough and “grain mixtures.”

And in 2002, Ajinomoto asked that anything else it might have previously overlooked, referred to as “use in food in general,” be given GRAS status. None of these GRAS notices elicited any objections from the FDA.  Nothing that Big Food asks for is even questioned any more.

Included in the 2001 “everything else” notification from Ajinomoto were some details of a 30-day toxicity study using beagles. Despite findings that included dogs that had developed a pituitary gland cyst, discoloration of the lungs, an enlarged uterus and “significantly” lower prostate weights, all that was considered “incidental and unrelated” to TG. Why they bothered to include a study that shows that their product causes harm to the animals studied can only be understood if you know how Ajinomoto operates.  Having done a study, they can later refer to the study that they did as though it proved that their product was “safe,” knowing that no one will challenge them. Such claims have great propaganda value.

The FDA had “no questions.”

Transglutaminase, here, there and everywhere

Lerner and Matthias have been warning for years about TG hidden in processed foods, saying it’s “unlabeled and hidden from public knowledge.” As we mentioned in another blog on TG several weeks ago, aside from “formed” meat products sold in supermarkets in the U.S. where the enzyme must be called out on the ingredient statement, TG can easily go undercover. 

And Ajinomoto has even added its own tips to help food manufacturers avoid labeling by providing an explanation of how TG is just a “processing aid,” as well as making available a letter authored by a law firm in Germany stating that aside from use in “formed” meat or fish, transglutaminase is “no ingredient” and as such in the EU does not have to be included on a food label. In fact, the lawyers go so far as to state that if a substance (such as TG) is “without any function in the finished product,” listing it on the ingredient label can “mislead the consumer.”

The FDA told us that if TG is used as a “processing aid” it’s considered an “incidental additive” and is “exempted from ingredient labeling.”

Even organic products aren’t safe from TG, as TG is considered A-OK to use it in organic foods, falling under the “allowed” generic category of “enzymes” on the USDA “National list of allowed and prohibited substances” in organic food and farming.

Perhaps the most devious use of this enzyme is to improve the appearance of gluten-free bakery products. Manufactured, microbial transglutaminase “functionally imitates” natural-tissue TG, which is known to be an autoantigen (a “self” antigen, reacting to something produced by the body that provokes an immune response) in those who suffer from celiac disease.  

Steering clear of transglutaminase

The TG story could very well be called a case against processed foods, as the only sure-fire way to avoid this gut-wrenching enzyme is to make/cook all your food from scratch. That being a very unlikely prospect these days, the next best thing is to avoid the following:

  • Low-fat and low-salt products, especially dairy and dairy substitutes;
  • Chicken nuggets, along with any other “formed” meat products;
  • Expensive cuts of meat being sold much cheaper than they should be (that especially is true for restaurants);
  • Sushi from unreliable sources, formed fish sticks and balls;
  • Veggie and tofu burgers; and
  • Cheaply produced pasta (TG is said to help when using “damaged wheat flour”).

When asked what he would consider to be an important take-away regarding transglutaminase, Professor Lerner told us that it would be for the FDA to “reconsider the classification of (manufactured) TG as GRAS.”


If you have questions or comments, we’d love to hear from you. If you have hints for others on how to avoid exposure to MfG, send them along, too, and we’ll put them up on Facebook. Or you can reach us at questionsaboutmsg@gmail.com and follow us on Twitter @truthlabeling.

Don’t get tangled up in MSG’s web of deception

The web is a treacherous place.  And the marketing done to sell toxic food additives may be the most dangerous territory of all.

According to Stanford University Professor Sam Wineburg,1 an article’s bylined author may not be its author. References that confer legitimacy may have little to do with the claims they anchor. Signals of credibility like a dot-org domain can be the artful handiwork of a Washington, D.C. public relations expert.

Wineburg cautions that unless you possess multiple Ph.D.’s – in virology, economics and the intricacies of immigration policy– often the wisest thing to do when landing on an unfamiliar site is to ignore it.2

Through years of painful experience, I have learned that posts about any “controversial” subject may harbor deceptive and misleading statements, half-truths, and affirmations from “experts” or “celebrities” who know nothing about the subject or are being generously “thanked” for their participation.  Not to be overlooked are details behind the controversy left untold.

In his article, Wineburg tells us that “Learning to ignore information is not something taught in school. School teaches the opposite: to read a text thoroughly and closely before rendering judgment. Anything short of that is rash.  But on the web, where a witches’ brew of advertisers, lobbyists, conspiracy theorists and foreign governments conspire to hijack attention, the same strategy spells doom. Online, critical ignoring is just as important as critical thinking.” 

The “controversial” story I know a lot about is the story about the alleged safety of monosodium glutamate (a.k.a. MSG).  The stories told about MSG and its toxic constituent, manufactured free glutamate (MfG) have two arms.  The first arm reaches out to you with warm fuzzy feel-good words that trigger visions of delicious, savory food, all due, so you are told, to this flavor enhancer that is being promoted.

The second arm that Wineburg was talking about brings you words designed to convince skeptics that MSG is a harmless, even beneficial, food additive.  And that arm extends out to TV, YouTube, and print media and embraces the Internet.

A stunning example recently appeared in an article titled Food Science Babe: MSG myths persist despite decades of research.  It was published on 5/13/2021 at the website agdaily.com, which is quite an interesting story all on its own. But more about that another time.

Adrienne Samuels

References

1. Sam Wineburg, Professor of Education and (by courtesy) History, Stanford University

2. https://theconversation.com/to-navigate-the-dangers-of-the-web-you-need-critical-thinking-but-also-critical-ignoring-158617 (Accessed 5/15/2021)

About The Truth in Labeling Campaign

The Truth in Labeling Campaign was incorporated in 1994 as a nonprofit organization dedicated to securing full and clear labeling of all processed food.

We are an all-volunteer group funded entirely through donations. Neither our staff nor our directors are paid. We rent no offices, and we use no professional fund raisers. Even the cost of disseminating information is primarily borne by volunteers. Our activities, many described in our website at: www.truthinlabeling.org, have included visits to congresspersons and scientists, attendance at food industry meetings, testimony before representatives of the U.S. Food and Drug Administration (FDA), and filing a lawsuit against the FDA.

But more importantly, we have been making information on the toxic potential of MSG and where it is hidden in food, pharmaceuticals, cosmetics, dietary supplements, pesticides and fertilizers and vaccines, available to consumers.

This organization was founded by Jack Samuels, a health care professional who had an acute, life-threatening sensitivity to MSG, and Adrienne Samuels, an experimental psychologist by training with expertise in research design, methodology, and statistics. Both had the skills needed to understand the science underlying Jack’s life-threatening sensitivity, along with the ability to distinguish between the fact of his sensitivity and the fiction generated by those who profit from the manufacture and sale of MSG. Adrienne possessed the knowhow to recognize design flaws in research reports – including those research reports that claimed to have found that MSG is “safe.” The first (and ongoing) project of The Truth in Labeling Campaign (TLC) was to secure identification of processed free glutamic acid (MSG) whenever and wherever it occurs.

For over 30 years, concerned consumers have tried to work with the FDA to resolve this identification issue, but have found no evidence that the FDA is ever going to act on their behalf. It appears that only through a true grassroots effort might the FDA’s refusal to require labeling of MSG be resolved. It was with this in mind that the TLC joined with 29 petitioners, whose ranks included physicians, researchers, and parents acting on behalf of their MSG-sensitive children, to file a Citizen Petition asking the FDA to require labeling of all MSG found in processed foods.

The Citizen Petition was followed by a lawsuit that the FDA easily had set aside. The FDA had only to invoke the Administrative Procedures Act (APA), which allows agencies of the U.S. government to tell the court what material it may or may not look at. Through use of the APA, the FDA was able to withhold evidence contained in its own files that testifies to the fact that MSG has toxic potential.


If you have questions or comments, we’d love to hear from you. If you have hints for others on how to avoid exposure to MfG, send them along, too, and we’ll put them up on Facebook. Or you can reach us at questionsaboutmsg@gmail.com and follow us on Twitter @truthlabeling.

MSG, the secret ingredient that makes a pet food a ‘success’

For most pet owners, the proof of quality, flavorful pet food products is in watching our furry friends enjoy their food. When a new diet is introduced to a pet and it stimulates active consumption, it’s considered palatable, and therefore a success. — Kemin Industries

Your idea of a successful food for your pet is probably one that will nourish your pup or kitty and help them live a long, healthy life. But for pet food companies, success is measured by how quickly a dog or cat eagerly eats up every last bite of the same food every single day.

Palatability is a key phrase in the industry. And to ensure that the food is palatable, or tasty and appetizing to the pet, a “secret” ingredient is added — one called a “palatant.”

Palatants are big business. These additives coerce an animal into consuming what’s placed in front of it (even if it’s an unappetizing-looking bowl of hard, brown pellets) using exactly the same method that makes Cheetos irresistible or gets Doritos to taste like the most delicious thing you’ve ever put in your mouth. You know the secret ingredient as monosodium glutamate (MSG), but it’s really the manufactured free glutamate (MfG) in the MSG that triggers our taste buds and our animals’ taste buds, making them beg for more. MfG can be found in 40+ food ingredients.

Palatants, which are also called “digests,” are primarily made from either hydrolyzed animal or vegetable proteins, which invariably contain MfG. When a protein is hydrolyzed it will always create excitotoxic – brain damaging — amino acids. It doesn’t matter if that hydrolyzed protein is put in dog food or a can of tuna you eat for lunch, it will contain MfG, the brain-damaging ingredient found in MSG.

Now, if you plan is to carefully examine the labels of pet foods for this noxious ingredient, you won’t come away with much information. Palatants can be listed on the label as “natural flavoring,” “digest,” or simply incorporated into some other benign-sounding component of the food – both in bargain brands and pricy boutique ones.

There are, however, some pet foods that will tell you right on the package that they’re using MfG-containing hydrolyzed proteins.

The pea-protein gravy train

Currently, the biggest darling of the food industry is widespread, multi-purpose pea protein. It’s a cheap ingredient used to bump up protein content in scores of bars, drinks, powders for smoothies and fake foods. Read more about it here.

When used in pet food, it’s advertised as an easily digestible source of protein, and is typically found in allergy, grain-free and limited protein diets.

Purina is one of many major pet food manufacturers that uses pea protein in its dog food formulas. While consumers are starting to realize that pea protein in human foods contains excitotoxic, brain-damaging MfG, it appears that same level of concern doesn’t apply to what we feed our pets. That is, until we learn that something has gone terribly wrong.

The mysterious heart ailment associated with grain-free pet foods

In 2018 the FDA issued an alert about grain-free pet food being implicated in untold numbers of otherwise healthy dogs and cats developing dilated cardiomyopathy, a disease of the heart muscle that can come on slowly and ultimately be fatal.

In typical FDA slow-motion style, the agency first received reports of the potential connection back in 2014, yet waited four years to warn pet owners. Now we know that all breeds, ages and sizes of dogs have been involved in the 560 accounts the FDA received (which most certainly are only a fraction of the actual number of cases).

Interestingly, no heavy metal compounds were found in the foods tested, but over 90 percent of the food consisted of grain-free formulas containing pea and/or lentil protein, i.e., MfG.

Could the excitotoxic amino acids in those ingredients have triggered this deadly heart condition? It’s pretty much a given that we will never learn more from the FDA. To even consider these highly processed, toxic vegetable proteins as a potential cause of this tragedy is something that agency will never, ever do.

The U.S. pet food industry is predicted to reach $30 billion in the next two years, with more and more expensive, highly advertised and “gourmet” brands on the market. Despite all the glowing package claims and pictures of fish, meat and poultry, the contents generally consist of low-quality, toxic ingredients.

And sadly, our dogs and cats are becoming overweight, morbidly obese, diabetic and sick at an ever-increasing rate – just as are their human companions.

If you have questions or comments, we’d love to hear from you. If you have hints for others on how to avoid exposure to MfG, send them along, too, and we’ll put them up on Facebook. Or you can reach us at questionsaboutmsg@gmail.com and follow us on Twitter @truthlabeling.

FDA claim that MSG is GRAS puts it in violation of its own rules


BY FDA REGULATIONS found in the Federal Food, Drug, and Cosmetic Act and in the FDA Code of Federal Regulations, the use of a food substance may be GRAS (generally recognized as safe) either through scientific procedures or, for a substance used in food before 1958, through experience based on common use

In short, to be designated FDA GRAS, an ingredient must be:

1) Tested for safety using scientific procedures, or

2) Known to be safe through experience based on common use in food prior to January 1958.

Monosodium glutamate (MSG) does not meet that standard and therefore does not meet the FDA requirements for GRAS status.

The MSG in use today has never been tested for safety. Although the glutamate industry has turned out badly flawed studies on the “safety” of MSG (using toxic material in placebos, for example), no one outside of the glutamate industry would ever claim that any of those studies qualified as “scientific” procedures.

The MSG in use today, made with glutamate created by genetically modified bacteria that excrete glutamate through their cell walls, was only invented in 1957, allowing no time to demonstrate safe use through experience (based on common use in food) prior to 1958. The MSG in use today could not have been grandfathered GRAS in 1958 because it didn’t exist prior to 1957.

In 1969, it was first observed that manufactured free glutamic acid, the essential ingredient in MSG, is an excitotoxic amino acid. When glutamate is ingested in controlled quantities, it is essential to normal function. But when ingested in excess, it causes brain damage, leading to a variety of abnormalities.

Prior to 1957, when glutamate was produced by extracting it from protein, there was not enough manufactured free glutamate added in food to cause glutamate to become excitotoxic. That changed in 1957 after glutamate came to be produced in virtually unlimited quantities.

Resources

Sections 201(s) and 409 of the Federal Food, Drug, and Cosmetic Act
FDA’s implementing regulations in the Code of Federal Regulations, 21 CFR 170.3, 21 CFR 170.30, and 21 CFR 170.30(b


If you have questions or comments, we’d love to hear from you. If you have hints for others on how to avoid exposure to MfG, send them along, too, and we’ll put them up on Facebook. Or you can reach us at questionsaboutmsg@gmail.com and follow us on Twitter @truthlabeling.

Are you feeding your infant brain-damaging additives?

In 1969 the moms and dads of America were promised by the top three baby-food manufacturers that monosodium glutamate would be taken out of their products.

Sure, the baby food executives whined and complained and told how the public had been “unnecessarily alarmed and confused,” but they had hit a brick wall. Dr. John Olney, a top researcher at the Washington University School of Medicine in St. Louis, had recently published data showing that when newborn mice were exposed to the additive, they suffered extensive brain damage and endocrine disorders, and he coined the term “excitotoxin” to describe monosodium glutamate. As the late Dr. Jean Mayer, a highly respected nutritionist who taught at Harvard for 25 years (and went on to be named president of Tufts University), said at the time: “I would take the damn stuff out of baby food.”

But half a century later, that “damn stuff” is still being fed to babies – only now added to infant formula.

A formula for disaster

Asked to report on the use of toxic manufactured free glutamate (MfG) in infant formula, we were appalled by the many articles available online that talked of the pros and cons of using various brands, but never once mentioned the presence of excitotoxins.

While monosodium glutamate may have been removed from those little jars of baby food, the same excitotoxic glutamic acid found in monosodium glutamate, now in ingredients such as whey protein concentrate and soy protein isolate, began appearing in infant formula. One product made by Enfamil shockingly lists among its ingredients monosodium glutamate, advising caregivers that it can be continued on as a “milk substitute in the diet of children.”

There are a variety of ways MfG harms the body. When Olney testified in 1972 before the Senate Select Committee on Nutrition and Human Needs, he was attesting to the brain damage and subsequent endocrine disorders caused by the MfG in monosodium glutamate when fed to the very young.

Now, people realize that monosodium glutamate also causes adverse reactions such as asthma, migraine headache, irritable bowel, skin rash, seizures, and heart irregularities.

But along the way to this enlightenment, the link between MfG and brain damage seems to have been forgotten. Perhaps that’s because you can’t see brain damage with the naked eye. There’s no pain, no upset stomach, no itching or wheezing.

And stealthily, the glutamate industry has invested millions of dollars in propaganda intended to reassure the public that monosodium glutamate is merely a harmless food additive.

It’s not that health authorities don’t seem to care what’s in infant formulas. The public has been alerted to various toxic ingredients that have been found in these products over the years, including melamine (a compound used to make plastics) and perchlorate (a chemical found in rocket fuel). In fact, the plastic additive BPA has been banned from baby bottles.

But there’s no warning about excitotoxins.

That’s why if you’re thinking of using – or currently use — infant formula, it’s essential that you read the ingredients. Think carefully about the chemicals that are commonly used in these products and beware of hidden excitotoxins.

In March, 2019, we found the following 10 brands of infant formula listed at Amazon.com and searched out their ingredients. These included:

  • Enfamil,
  • Similac,
  • Earth’s Best,
  • Kirkland Signature
  • Good Start
  • Happy Baby
  • Good Sense
  • Member’s Mark
  • Plum Organics
  • Parent’s Choice

In the following ingredient lists, excitotoxic ingredients are highlighted. Only ones that make up more than 1 or 2 percent of the product are included.

Note: The excitotoxin content of milk depends on whether or not whole milk is used in the milk product. If whole milk is used, the excitotoxin content of the milk depends on the pasteurization process (higher heat for longer time frees more glutamic acid and aspartic acid from the original milk protein). If low fat or non-fat milks are used, there will be excitotoxin in the low fat and non-fat milk because those milks are made from milk powder which contains free glutamic acid and free aspartic acid as unavoidable consequences of manufacture.

Enfamil PREMIUM Infant Formula, Powder

NONFAT MILK, LACTOSE, VEGETABLE OIL (PALM OLEIN, COCONUT, SOY, AND HIGH OLEIC SUNFLOWER OILS), WHEY PROTEIN CONCENTRATE

Similac Advance

Nonfat Milk, Lactose, Whey Protein Concentrate, High Oleic Safflower Oil, Soy Oil, Coconut Oil, Galactooligosaccharides…

Earth’s Best Organic Dairy Infant Formula with Iron

Organic Lactose, Organic Nonfat Milk, Organic Oils (Organic Palm or Palm Olein, Organic Soy, Organic Coconut, Organic High Oleic Safflower or Sunflower Oil), Organic Whey Protein Concentrate

Kirkland Signature Infant Formula

Nonfat milk, lactose, whey protein concentrate, high oleic safflower oil, soy oil, coconut oil, galacto-oligosaccharides…

Gerber Good Start non-GMO powder Infant Formula

WHEY PROTEIN CONCENTRATE (FROM COW\’S MILK, ENZYMATICALLY HYDROLYZED, REDUCED IN MINERALS), vegetable oils (, PALM OLEIN, SOY, COCONUT, AND , HIGH-OLEIC SAFFLOWER, OR , HIGH-OLEIC SUNFLOWER) , LACTOSE, CORN MALTODEXTRIN

Happy Baby Organic Stage 1 Infant Formula Milk Based Powder with Iron

Organic non-fat milk, organic whey protein concentrate

Good Sense

Corn syrup, non-fat milk, whey protein hydrolysate

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Nonfat Milk, Lactose, Vegetable Oils (Palm Olein, Coconut, Soy, High Oleic (Safflower Or Sunflower] Oil), Whey Protein Concentrate, Galactooligosaccharides…

However, infant formula isn’t the only way a baby can be exposed to MfG.

The bizarre connection between Big Food and breast milk

Research done in the 1980s and 1990s confirmed that monosodium glutamate and other ingredients that contain MfG are passed by pregnant women to their fetuses, and by lactating mothers to their newborns. Studies found that MfG can cross the placenta during pregnancy, can cross the blood brain barrier (BBB) in an unregulated manner during development, and can pass through the five circumventricular organs that lie outside the BBB.

In the 1960s and 1970s Olney described the brain damage done by monosodium glutamate, which was found to destroy brain cells when fed in large quantity to animals whose brains were not protected by blood brain barriers. Olney observed that the BBBs of fetuses and newborns seen in the laboratory left certain areas of their developing brains unprotected, and he cautioned that human fetuses and newborns were similarly at risk. The unprotected areas included the arcuate nucleus of the hypothalamus, the area of the brain that, when undamaged, regulates reproduction and weight (telling us when to stop eating).

Every woman who breast feeds her baby will want to make sure that her diet does not contain excitotoxins – or contains as few as possible. That list includes aspartic acid (found in aspartame, e.g., Nutrasweet, Equal, Amino Sweet, and other aspartame-based sugar substitutes); L-cysteine, found in dough conditioners, and the many ingredients that contain MfG.

Certainly, every parent wants a healthy baby, but there are industry giants out there who only care about their bottom lines. Consumer beware.


If you have questions or comments, we’d love to hear from you. If you have hints for others on how to avoid exposure to MfG, send them along, too, and we’ll put them up on Facebook. Or you can reach us at questionsaboutmsg@gmail.com and follow us on Twitter @truthlabeling.

This must have slipped by when Google wasn’t looking!

About as rare as finding a flock of flamingos in Central Park is doing a search on Google for monosodium glutamate (a.k.a. MSG) where the top results don’t all sing the praises of MSG.

This article, found fairly high up on a Google search is headlined: “Chinese celebrity chef Ken Hom says ‘MSG is used only by lazy cooks.’

Ordinarily, a Google search for MSG will deliver pages and pages of articles that proclaim the safety and benefits of feasting on foods enhanced with MSG, sometimes authored by celebrity chefs who speak out on the glories of use of MSG. The claim that renown chefs use MSG in their cooking has long been a staple of glutamate-industry marketing. Often involved are well-known restauranteurs or celebrity chefs such as Andrew Zimmern, Grant Achatz, David Chang, Eddie Huang, Heston Blumenthal and Chris Koetke who celebrate the “wonders” of cooking with MSG.

Foodies will recognize the name of the legendary Julia Child, whose cookbook, Mastering the Art of French Cooking, is still a best-seller after 60 years. It’s well known that she would never use MSG in a recipe. Yet somehow the glutamate people got to her, and late in life she was heard on radio extolling the virtues of MSG.

More recently, Andrew Zimmern, celebrity chef & TV personality, served as Master of Ceremonies at the World Umami Forum, put on by the U.S. manufacturer of MSG. Zimmern is quoted from time to time talking about the virtues of MSG, but unless he has just started using MSG in new recipes, he doesn’t appear to cook with it.

Part of what sells MSG to consumers is the people making the presentations (a.k.a. sales pitches). The glutamate industry has capitalized on that fact, and certain celebrity chefs have seen value in testifying to the fact that MSG enhances the flavor of food while ignoring the fact MSG produced since 1957 is a toxic food additive.

Or, as chef Hom says, MSG is for “lazy cooks.”


If you have questions or comments, we’d love to hear from you. If you have hints for others on how to avoid exposure to MfG, send them along, too, and we’ll put them up on Facebook. Or you can reach us at questionsaboutmsg@gmail.com and follow us on Twitter @truthlabeling.