Aspartame: the placebo used in ‘MSG-is-safe’ studies

But to make sure the conclusion that MSG is harmless would be beyond reproach, glutamate-industry researchers guaranteed that subjects would react to placebos with the same reactions that are caused by MSG. They did that by using aspartame as the toxic ingredient in their placebos, which worked well for them because the aspartic acid in aspartame and the glutamic acid in MSG cause virtually identical reactions (as well as identical brain damage). Having set that up, glutamate-industry researchers (and the propaganda artists who quote them) will say “These people aren’t sensitive to MSG, they reacted to the ‘placebo’ too.”

If you have questions or comments, we’d love to hear from you. If you have hints for others on how to avoid exposure to MfG, send them along, too, and we’ll put them up on Facebook. Or you can reach us at questionsaboutmsg@gmail.com and follow us on Twitter @truthlabeling.

Don’t expect to learn the truth about MSG from today’s U.S. researchers

I’m certainly not afraid to speak out. I’ve been speaking out on the hazards of MSG for more than 30 years along with Jack Samuels, slowing down only to grieve his death and tell his story, “It Wasn’t Alzheimer’s, It Was MSG.” Given that the US maker of MSG controls the medical journals, the media, and the FDA as well as legislators who might have FDA oversight, speaking out has been limited to updating our fact-based webpage, making it easier to use and writing blogs. And I filed three Citizen Petitions with the FDA requesting that MSG and the toxic glutamate in it be stripped of their GRAS (generally recognized as safe) status. But apparently those who would or could do something for the welfare of the American people were not paying attention.

But something changed in the 2020s. Maybe the pandemic caused some soul searching – at least in Asia and Africa. Maybe there was so much free-glutamate in processed food (free-glutamate being the toxic ingredient in MSG and all other flavor enhancers) that the numbers of people reacting to flavor enhancers escalated to the point that it couldn’t be denied. Or maybe Ajinomoto’s campaigns to clear MSG of its bad name backfired, and people realized that it was lies that were being told over and over and over again in industry propaganda dressed up as news — or lies being told by celebrity chefs who really don’t use MSG in their cooking.

Today a friend of the Truth in Labeling Campaign sent me a copy of this research: “Worldwide flavor enhancer monosodium glutamate combined with high lipid diet provokes metabolic alterations and systemic anomalies: An overview” that included the warning, “This comprehensive review formulates health care strategies to create global awareness about the harmful impact of [MSG with a high lipid diet] on the human body and recommends the daily consumption of more natural foods rich in antioxidants instead of toxic ingredients.”

And that wasn’t the only warning I’ve seen in recent years. Others have included:

  • Study of the Toxic Effects of Monosodium glutamate on the Central Nervous System (Egypt)
  • Entering a new era of quantifying glutamate clearance in health and disease (Canada)
  • Anti-inflammatory activity of ginger modulates macrophage activation against the inflammatory pathway of monosodium glutamate (Egypt)
  • Targeting metabotropic glutamate receptors for the treatment of depression and other stress-related disorders (USA)
  • Modulation of immune functions, inflammatory response, and cytokine production following long-term oral exposure to three food additives; thiabendazole, monosodium glutamate, and brilliant blue in rats (Egypt)
  • Natural products as safeguards against monosodium glutamate-induced toxicity (Iran)
  • Dietary monosodium glutamate altered redox status and dopamine metabolism in lobster cockroach (Nauphoeta cinerea) (Nigeria)
  • Antiapoptotic and antioxidant capacity of phytochemicals from Roselle (Hibiscus sabdariffa) and their potential effects on monosodium glutamate-induced testicular damage in rat (Egypt)
  • Monosodium Glutamate (MSG)-Induced Male Reproductive Dysfunction: A Mini Review (Nigeria)

In the 1980s, researchers focused on identifying and understanding abnormalities associated with glutamate, often for the purpose of finding drugs that would mitigate glutamate’s adverse effects. It is well documented that free glutamate is implicated in kidney and liver disorders, neurodegenerative disease, and more. By 1980, glutamate-associated disorders such as headaches, asthma, diabetes, muscle pain, atrial fibrillation, ischemia, trauma, seizures, stroke, Alzheimer’s disease, amyotrophic lateral sclerosis (ALS), Huntington’s disease, Parkinson’s disease, depression, multiple sclerosis, schizophrenia, obsessive-compulsive disorder (OCD), epilepsy, addiction, attention-deficit/hyperactivity disorder (ADHD), frontotemporal dementia and autism were on the rise, and evidence of the toxic effects of glutamate were generally accepted by the scientific community. A November 15, 2020 search of the National Library of Medicine using PubMed.gov returned 3872 citations for “glutamate-induced.”

Millions of health care dollars could be saved by simply considering MSG when making diagnoses. And if the truth about the toxic potential of free glutamate were told and its use in food reduced, disease and disability would certainly be reduced with it. Given that free glutamate plays a role in a wide variety of abnormalities, decreasing the amount of free glutamate added through ingestion of free glutamate in flavor enhancers and protein substitutes to the body’s glutamate pools certainly wouldn’t do any harm, and many have argued that evidence says that decreasing the presence of excitotoxic amino acids in processed and ultra-processed foods is called for. It’s time to follow the science of independent researchers and not the propaganda spewed forth by the glutamate industry.

Adrienne Samuels


If you have questions or comments, we’d love to hear from you. If you have hints for others on how to avoid exposure to MfG, send them along, too, and we’ll put them up on Facebook. Or you can reach us at questionsaboutmsg@gmail.com and follow us on Twitter @truthlabeling.

Parkinson’s, Alzheimer’s, ALS, MS, epilepsy and 10+ other diseases all have this in common

It looks like Ajinomoto is fighting tooth and nail, pulling out all the stops to convince the public that their brain damaging (excitotoxic) monosodium glutamate (MSG) is harmless. They’re pouring millions of dollars into buying advertising space in newspapers throughout the world, issuing press releases, covertly publishing YouTube commercials dressed up as news, buying testimonials from celebrity chef, sports personalities, and good-looking young women who call themselves “sci moms.” They’ve mastered brainwashing on social media. Yet people keep getting sick after eating MSG. Not everyone, of course, just lots of people. And Ajinomoto’s MSG sales have been slipping.

There’s something else, too. Scientists are beginning to realize that somehow glutamate has something to do with increases in Parkinson’s disease, Alzheimer’s disease, multiple sclerosis, stroke, ALS, autism, schizophrenia, depression, obsessive-compulsive disorder (OCD), epilepsy, ischemic stroke, seizures, Huntington’s disease, addiction, attention-deficit/hyperactivity disorder (ADHD), frontotemporal dementia, and autism. No one has yet identified a cause and effect relationship, but the scientific community now recognizes that glutamate is associated with each of them. Data? A January 18, 2020 Medine search (www.pubmed.gov) for “glutamate-induced,” returned 3742 references.

If you have questions or comments, we’d love to hear from you. If you have hints for others on how to avoid exposure to MfG, send them along, too, and we’ll put them up on Facebook. Or you can reach us at questionsaboutmsg@gmail.com and follow us on Twitter @truthlabeling.

The art of lying about the safety of MSG

Straight from the horse’s mouth: How to tell your story, market your idea and sell your product without mentioning that its use could be lethal

Nobody does it better than Ajinomoto and their team of public relations specialists.   Since 1957, when they changed the way they manufactured monosodium glutamate (a.k.a. MSG), and reports of reactions to MSG began to circulate, they’ve waged one hell of an effective marketing campaign aimed at convincing consumers (and anyone who might influence consumers) that MSG is harmless. And their success is evidenced by the facts that researchers in the United States rarely study the effects of MSG toxicity and medical journals don’t often publish studies that even suggest MSG might be toxic. Mainstream media dutifully carry Ajinomoto’s message while physicians don’t diagnose for MSG-sensitivity, and the FDA gives false testimony to the safety of MSG.

Recently, Jeryl Brunner writing in Forbes, interviewed one of Ajinomoto’s own, who showed us how it’s done.

Building Tia Rains’ expert/celebrity status

Brunner’s interview starts with Jeryl Brunner explaining that Tia Rains, an Ajinomoto executive, is “crusading to change the perception of monosodium glutamate.” Following are the feel-good words you’re supposed to associate with Tia Rains (without realizing that you’re being brainwashed).  They’re used interchangeably by Rains and Brunner to build Rains’ expert/celebrity image.

  • Nutrition (nutritionist)
  • Scientist
  • Nutritional scientist
  • Her true calling
  • Mastering the art
  • Devoted
  • Educating
  • Optimize
  • Understand
  • Guru
  • Inspired
  • Swimmer (a sports figure)
  • PhD
  • Passion
  • Research

Then there are statements about Tia Rains’ “crusade”:

  • Her specialty is debunking misperceptions of maligned foods. 
  • She’s focused on translating nutrition science into application to advance public health
  • She’s dedicated to mapping out a communication approach that resonates with her audience.

The headline actually reads — “For Decades, This Nutrition Scientist And Marketing Guru Has Inspired Millions To Change Misperceptions.” 

Brunner goes on to say,

Nutrition scientist Tia Rains is devoted to educating people about the food they eat. Her passion for nutrition developed from being a child competitive swimmer. Rains knew that nutrition could optimize her performance and she wanted to understand how.

“For two decades Rains has spent most of her professional career mastering the art of nutrition communications. A PhD in nutritional sciences, her specialty is debunking misperceptions of maligned foods. 

“Rains started at Kraft Foods where she found her true calling at the nexus of science and application. Then she lead nutrition research at a contract research organization. From there she moved to the Egg Nutrition Center where she led a successful effort against the public vilification of eggs.

“Her latest endeavor is crusading to change the perception of monosodium glutamate, better known as ‘MSG.’ As Vice President of Customer Engagement and Strategic Development at Ajinomoto Health & Nutrition North America, Rains is a health and nutrition advocate within the food and nutrition industry. She is focused on translating nutrition science into application to advance public health.” 

Here’s how Rains would inspire you to change your opinion on MSG being toxic, using “art and science.”

Ordinarily, there would be five parts to the “art and science” of generating propaganda:

1. A positive image of the person delivering the message (an expert or a celebrity)

2. A recitation of the good things about the product,

3. A recitation of how the product (MSG) has been maligned,

4. A recitation of what’s bad about those who contradict claims that the product is worth buying, and,

5. A recitation of alleged “facts” – lies that people will be told about MSG.

In Brunner’s article, however, the focus is on the expertise of the person making the presentation as she exposes the root of all this “misinformation” (which, Rains says, is a 1968 article in the New England Journal of Medicine).  

To accomplish that, Rains and Brunner use words that will resonate with her audience as she:  

Builds sympathy for poor maligned MSG:

  • “MSG is one of the most baselessly demonized ingredients in American history.”
  • “We’re attempting to overturn a terrible and long history of xenophobia and misinformation.”
  • “MSG became an easy target and the stigma took hold.”  

Praises the success of her efforts to convince people that MSG is “safe”:

  • “To date, her efforts have contributed to more than twelve million Americans becoming more positive toward the ingredient.”   

Reinforces the positive image that Rains has built for herself:

  • “I hope we can get to a place where we’re leaning more on science than personal feeling, or even fear.”
  • “Every time I present facts and get someone to shift their perception, I’m reminded of why I do what I do.”   
  • “As a scientist, I’m an analytical thinker by training and recognize the importance of research and data. I am able to make science accessible and understandable for the average consumer. But I also think critically about the variety of factors that inform a perception and then see how we can work with researchers and experts to examine why they persist. Credible data is important when creating successful marketing campaigns.”

Urges followers to deliver a balance of logic and emotion:

  • Be logical.  Logic gives people confidence in the message.
  • Play to the audience’s emotions.  Emotion allows people to take ownership of Rains’ campaign and work to have others work with her to change their negative opinions about MSG.

Speaks of the benefits of using MSG:

  • It’s critical for people to taste what MSG does to food and truly experience it. 
  • MSG can be used as a replacement for table salt.

Recites some of the half-truths told by the glutamate industry:

  • “Decades of research validates MSG’s safety.”

(NOTE: the research said by Rains to validate MSG’s safety is badly flawed, in some cases using placebos made of excitotoxic amino acids that cause reactions identical to those caused by MSG.)

  • “Public health organizations around the world stand by its use in the food supply.” 

(NOTE: The organizations referred to by Rains did no research of their own on the safety of MSG (neither library nor laboratory research), but were given material to review by Ajinomoto and Ajinomoto’s agents, which includes the FDA.)

For more information see: https://www.truthinlabeling.org/assets/industrys_fda_final.pdf

For obvious reasons, neither Brunner nor Rains mentions brainwashing which, we have observed, is her basic modus operandi.  Brainwashing can be accomplished in many different ways. Here it’s done by pairing the three letters MSG with feel-good words.  Just as food was paired with ringing a bell for Pavlov’s dogs to condition them to salivate when a bell was rung, pairing “MSG” with happy, soothing words will make people feel good every time they think “MSG.”

What more could a propaganda artist ask for than a couple of pages of subtle brainwashing displayed on the pages of Forbes.


If you have questions or comments, we’d love to hear from you.  And if you have hints for others on how to avoid exposure to MfG, send them along, too, we’ll put them up on Facebook.  You can also reach us at questionsaboutmsg@gmail.com and follow us on Twitter @truthlabeling

Warning about the hazards of MSG can be hazardous to your reputation

By Linda and Bill Bonvie

Being accused of racism these days is no small matter. And those of Asian descent have seen an increase in incidents of racism targeting them.

So, when a reader review at Amazon.com appeared about our book, “A Consumer’s Guide to Toxic Food Additives,” accusing us of “promoting myths rooted in racism,” it was a bit of a shock, to say the least.

This reviewer, whose comment is called the “top” one from the U.S. (also somehow bumping any other reviews into obscurity), was in fact simply parroting information gleaned from various “news” stories appearing across the web.

It may sound crazy, but just by including warnings about consuming MSG in that book, we now were being accused of spreading a “myth deeply rooted in xenophobia.” In effect, consumer protection had somehow become redefined as ethnic bigotry directed specifically at Asian Americans.

You may be wondering, as we were, just where such a bizarre idea could have originated, and the answer is one that clearly shows how much influence PR agencies – especially large, well- connected ones – have over media of all sizes these days.

It stands to reason that manufacturers of questionable additives would attempt to counter warnings about their products with whatever industry-sponsored hype they could devise. But never did charges of “racism” enter into it until the “global communications” firm Edelman Public Relations entered the scene. They are being paid millions of dollars by Ajinomoto, the world’s largest manufacturer of monosodium glutamate, to conjure up the concept that legitimate concerns about the safety of MSG were nothing but racist myths.

Taking a cue from the removal of “misinformed historical symbols,” according to an Edelman press release, the Ajinomoto creative team apparently had an ‘aha moment’ when it coined “xenophobia-born misinformation” in an attempt to divert attention away from any negative science and adverse reactions associated with MSG.

Has it worked? If you go by the amount of media coverage received, such as this headline at CNN saying, MSG in Chinese food isn’t unhealthy – you’re just racist, activists say, this imaginary imagery seems to have taken hold, even filtering down to that “reader review” of our book. But Edelman, despite its ability to have media lists at its beck and call to run articles on how the term “No MSG,” constitutes racism, can’t seem to even monitor its own client list for conflicts of interest.

A question sent to the Del Monte press office about its College Inn broth product, for example, took a surprising turn with a return email from an Edelman representative speaking on the company’s behalf.

A group of products that say "No MSG" on the label.

Being that the College Inn product sports a rather large “No MSG” symbol on the package front, we asked our Edelman contact if, according to their own high-profile campaign, that would constitute the same type of “racism” and “xenophobia” that we were accused of.

But despite several attempts to elicit an answer, Edelman has now gone dark on us. (We wondered if Del Monte would be looking for another PR firm should its executives connect the dots.)

Which only goes to show how even the best-intentioned causes, such as shining a spotlight on racism, can be distorted and manipulated by industry shills to cast other good causes, such as consumer protection, in a bad light.

Only in this case, the fact remains that keeping MSG out of your diet is no more “racist” than avoiding apple pie sweetened with HFCS is “un-American.”


If you have questions or comments, we’d love to hear from you.  And if you have hints for others on how to avoid exposure to MfG, send them along, too, we’ll put them up on Facebook.  You can also reach us at questionsaboutmsg@gmail.com and follow us on Twitter @truthlabeling

Excitotoxins in processed food: The best guarded secret of the food and drug industries

Excitotoxicity is the pathological process by which nerve cells are damaged or killed by excessive stimulation by neurotransmitters such as glutamic acid (glutamate).

In 1969 when researcher Dr. John Olney of Washington University in St. Louis observed that process in his laboratory, it should have resulted in sweeping changes in how food additives are regulated. 

He noted that glutamate fed as monosodium glutamate (MSG) to laboratory animals killed brain cells and subsequently caused gross obesity, reproductive dysfunction, and behavior abnormalities.

Before that, the world knew nothing of what Dr. Olney had dubbed “excitotoxins.” And after Olney’s discovery, the existence of free excitotoxic amino acids present in food became the best-guarded secret of the food and drug industries.

Today, excitotoxins present in food remain largely ignored or unknown, mostly because the rich and powerful food and pharmaceutical industries want it that way. A great deal of food industry profit depends on using excitotoxins to “enhance” the taste of cheaply made food. And a great deal of pharmaceutical industry profit depends on selling drugs to “cure” the diseases and disabilities caused by the excitotoxins in the food supply.

What are excitotoxins?

Excitotoxins are often amino acids, but not all amino acids are excitotoxins. The amino acid with the greatest excitotoxic footprint is glutamate. When present in protein or released from protein in a regulated fashion (through routine digestion), glutamate is vital to normal body function. It is the major neurotransmitter in humans, carrying nerve impulses from glutamate stimuli to glutamate receptors throughout the body. Yet, when present outside of protein in amounts that exceed what the healthy human body was designed to accommodate (which can vary widely from person to person), glutamate becomes an excitotoxic neurotransmitter, firing repeatedly, damaging targeted glutamate-receptors and/or causing neuronal and non-neuronal death by over exciting those glutamate receptors until their host cells die.

Technically speaking, neurotransmitters that over-stimulate their receptors to the point of killing the cells that host them are called excitotoxic neurotransmitters, and the resulting condition is referred to as excitotoxicity. Glutamate excitotoxicity is the process that underlies the damage done by MSG and the other ingredients that contain processed free glutamic acid (MfG). 

Glutamate is called a non-essential amino acid because if the body does not have sufficient quantities to function normally, any needed glutamate can be produced from other amino acids. So, there is no need to add glutamate to the human diet. The excitotoxins in MSG and other ingredients that contain MfG are not needed for nutritional purposes. MSG and many other ingredients have been designed to enhance the taste of cheaply made food for the sole purpose of lining the pockets of those who manufacture and sell them.

Glutamate neurotransmitters trigger glutamate receptors both in the central nervous system and in peripheral tissue (heart, lungs, and intestines, for example). After stimulating glutamate receptors, glutamate neurotransmitters may do no damage and simply fade away, so to speak, or they may damage the cells that their receptors cling to, or overexcite their receptors until the cells that host them die.

There’s another possibility. There are a great many glutamate receptors in the brain, so it’s possible that if a few are damaged or wiped out following ingestion of MfG, their loss may not be noticed because there are so many undamaged ones remaining. It is also possible that individuals differ in the numbers of glutamate receptors that they have. If so, people with more glutamate receptors to begin with are less likely to feel the effects of brain damage following ingestion of MfG because even after some cells are killed or damaged, there will still be sufficient numbers of undamaged cells to carry out normal body functions.

That might account for the fact that some people are more sensitive to MfG than others.

Less is known about glutamate receptors outside the brain – in the heart, stomach, and lungs, for example. It would make sense (although that doesn’t make it true) that cells serving a particular function would be grouped together. It would also seem logical that in each location there would be fewer glutamate receptors siting on host cells than found in the brain, and for some individuals there might be so few cells with glutamate receptors to begin with, that ingestion of even small amounts of MfG might trigger asthma, atrial fibrillation, or irritable bowel disease; while persons with more cells hosting glutamate receptors would not notice damage or loss.

Short-term effects of excitotoxic glutamate (such as asthma and migraine headache) have long been obvious to those not influenced by the rhetoric of the glutamate industry and their friends at the U.S. Food and Drug Administration. Hopefully, researchers will soon begin to correlate the adverse effects of glutamate ingestion with endocrine disturbances such as reproductive disorders and gross obesity. It is well known that glutamate plays an important role in some mental disorders and neurodegenerative diseases, but the fact that ingestion of excitotoxic glutamate might contribute to existing pools of free glutamate that could become excitotoxic, still needs to be considered. Finally, a few have begun to realize the importance of glutamate’s access to the human body through the mouth, nose and skin.

There are three excitotoxic amino acids used in quantity in food, cosmetics, pharmaceuticals, protein drinks and powders, and dietary supplements:

1) Glutamic acid — found in flavor enhancers, infant formula, enteral care products for invalids, protein powders, processed foods, anything that is hydrolyzed, and some pesticides/fertilizers.

2) Aspartic acid — found in low-calorie sweeteners, aspartame and its aliases, infant formula, protein powders, anything that is hydrolyzed, and

3) L-cysteine — found in dough conditioners.

According to Dr. Edward Group, the six most dangerous excitotoxins are: MSG (monosodium glutamate), aspartate, domoic acid, L-BOAA, cysteine, and casein.

If you have questions or comments, we’d love to hear from you.  And if you have hints for others on how to avoid exposure to MfG, send them along, too, we’ll put them up on Facebook.  You can also reach us at questionsaboutmsg@gmail.com and follow us on Twitter @truthlabeling

Resources

Dr. Edward Group The 6 Most Dangerous Excitotoxins. Global Healing Center.  (accessed 8/20/2016)

Blaylock RL. Excitotoxins: The Taste That Kills. Santa Fe, New Mexico: Health Press; 1994.

Olney JW. Brain Lesions, Obesity, and Other Disturbances in Mice Treated with Monosodium Glutamate; Science. 1969;164:719-21.  

Olney JW, Ho OL. Brain damage in infant mice following oral intake of glutamate, aspartate or cystine. Nature. 1970;227:609-611.

Olney, J.W. Excitatory neurotoxins as food additives: an evaluation of risk. Neurotoxicology 2: 163-192, 1980.

Olney JW. Excitotoxins in foods. Neurotoxicology. 1994 Fall;15(3):535-44.

Gudiño-Cabrera G, Ureña-Guerrero ME, Rivera-Cervantes MC, Feria-Velasco AI, Beas-Zárate C. Excitotoxicity triggered by neonatal monosodium glutamate treatment and blood-brain barrier function. Arch Med Res. 2014 Nov;45(8):653-9.

Verywellhealth.com.  An Overview of Cell Receptors and How They Work https://www.verywellhealth.com/what-is-a-receptor-on-a-cell-562554   (Accessed 5/5/2019)

‘Likely culprit’ in celiac disease hidden in processed foods

Why is Ajinomoto trying so hard to keep transglutaminase unlabeled?

Over the past few decades celiac disease (CD) has morphed into a “major public health problem.” Along with it, other autoimmune conditions such as diabetes, rheumatoid arthritis, inflammatory bowel disease and psoriasis, are also topping the charts as very common disorders with dozens of heavily advertised drugs created to treat them.

If you ask why, the knee-jerk response is typically that better testing has uncovered all these otherwise undisclosed conditions. But does that really explain things? And it certainly doesn’t take into consideration what experts refer to as large numbers of people with undiagnosed autoimmune diseases, especially CD.

Back in 2015 two researchers with expertise in metabolic diseases, Aaron Lerner, a professor at Tel Aviv University, and Torsten Matthias, affiliated with the AESKU.KIPP Institute in Germany, first sounded the alarm on a largely unknown, widely used food additive – an enzyme called transglutaminase (TG). At that time, they proposed a “hypothesis” linking TG used in food processing to celiac and other autoimmune diseases. Four years later, however, the pair stated that further research and observations have closed the “gaps” in our understanding of how TG is an “inducer of celiac disease.”   

Big Food’s favorite find to ‘glue’ things together

Transglutaminase, a.k.a. “meat glue,” is the darling of Big Food for lots of reasons: it can glue together scraps of fish, chicken and meat into whole-looking cuts (often called “Frankenmeats”); extend the shelf life of processed foods (even pasta); improve “texture,” especially in low-salt, low-fat products; make breads and pastries (particularly gluten-free ones) rise better, and, as one manufacturer puts it, allow for use of things that would ordinarily be tossed out — unappetizing leftovers and scraps of food that would “otherwise be considered waste ingredients, creating an added-value product.”

But more than just turning “waste ingredients” into new food products, there are a host of other reasons why you should do your best to steer clear of meat glue.

‘Tight junction dysfunction’

The 2015 research published by Lerner and Matthias detailed how certain food additives may be behind the steady rise of autoimmune diseases due to something called “tight junction dysfunctions,” which can set the stage for a wide variety of serious ailments, calling out transglutaminase as one of the commonly used food additives that can enhance “intestinal junction leakage.”

A subsequent study in 2019 recognized transglutaminase as a “likely culprit” in celiac disease.

In 2020, Lerner and Matthias published yet another paper on transglutaminase and celiac disease, calling it a “potential public health concern” and saying that they hope their review will “encourage clinical, scientific and regulatory debates on (its) safety to protect the public.”

Despite all the warnings and additional research, use of the enzyme is booming, and all its food uses are now considered GRAS (generally recognized as safe) by the FDA.

TG and MSG

The similarities between MSG and transglutaminase are quite noteworthy. Not only is the enzyme manufactured in great quantities by Ajinomoto (as is MSG) but the way TG is promoted by the company is remarkably similar to its long-running propaganda campaign claiming that MSG is a safe ingredient.

For example, Ajinomoto states on its websites and elsewhere that both MSG and TG are “found in food naturally,” are “safe,” used in many countries and considered GRAS in the U.S. by the FDA. And just as MSG supposedly in no way causes serious reactions, the company says that TG in no way causes celiac disease – in fact, under some circumstances the TG added to food can actually help CD patients, Ajinomoto says.

While transglutaminase is found naturally in the human body (as is glutamate), there is a significant difference between microbial TG (the manufactured additive) and “our own transglutaminase” says Lerner.  (Just as there is a major difference between manufactured MSG and the glutamate in your body).

That’s because the tissue TG produced in the body “has a different structure (from) the microbial sort, which allows its activity to be tightly controlled. Microbial transglutaminase itself could also increase intestinal permeability,” he says, “by directly modifying proteins that hold together the intestinal barrier.”

The FDA has “no questions”

While once the FDA pretended to look into the safety of a product before granting it GRAS status, not even that is done any more.  Now a company simply turns in a statement that a product should be referred to as GRAS, and it’s done.

Starting in 1998 Ajinomoto filed four notices of “self-determined” GRAS status for TG with the FDA. The first was to use TG in seafood. In 1999 they sent in more intended uses for hard and soft cheeses, yogurt, and “vegetable protein dishes/veggie burgers/meat substitutes.” In 2000 Ajinomoto sent another notice to the FDA regarding using transglutaminase in pasta, bread, pastries, ready-to-eat cereal, pizza dough and “grain mixtures.”

And in 2002, Ajinomoto asked that anything else it might have previously overlooked, referred to as “use in food in general,” be given GRAS status. None of these GRAS notices elicited any objections from the FDA.  Nothing that Big Food asks for is even questioned any more.

Included in the 2001 “everything else” notification from Ajinomoto were some details of a 30-day toxicity study using beagles. Despite findings that included dogs that had developed a pituitary gland cyst, discoloration of the lungs, an enlarged uterus and “significantly” lower prostate weights, all that was considered “incidental and unrelated” to TG. Why they bothered to include a study that shows that their product causes harm to the animals studied can only be understood if you know how Ajinomoto operates.  Having done a study, they can later refer to the study that they did as though it proved that their product was “safe,” knowing that no one will challenge them. Such claims have great propaganda value.

The FDA had “no questions.”

Transglutaminase, here, there and everywhere

Lerner and Matthias have been warning for years about TG hidden in processed foods, saying it’s “unlabeled and hidden from public knowledge.” As we mentioned in another blog on TG several weeks ago, aside from “formed” meat products sold in supermarkets in the U.S. where the enzyme must be called out on the ingredient statement, TG can easily go undercover. 

And Ajinomoto has even added its own tips to help food manufacturers avoid labeling by providing an explanation of how TG is just a “processing aid,” as well as making available a letter authored by a law firm in Germany stating that aside from use in “formed” meat or fish, transglutaminase is “no ingredient” and as such in the EU does not have to be included on a food label. In fact, the lawyers go so far as to state that if a substance (such as TG) is “without any function in the finished product,” listing it on the ingredient label can “mislead the consumer.”

The FDA told us that if TG is used as a “processing aid” it’s considered an “incidental additive” and is “exempted from ingredient labeling.”

Even organic products aren’t safe from TG, as TG is considered A-OK to use it in organic foods, falling under the “allowed” generic category of “enzymes” on the USDA “National list of allowed and prohibited substances” in organic food and farming.

Perhaps the most devious use of this enzyme is to improve the appearance of gluten-free bakery products. Manufactured, microbial transglutaminase “functionally imitates” natural-tissue TG, which is known to be an autoantigen (a “self” antigen, reacting to something produced by the body that provokes an immune response) in those who suffer from celiac disease.  

Steering clear of transglutaminase

The TG story could very well be called a case against processed foods, as the only sure-fire way to avoid this gut-wrenching enzyme is to make/cook all your food from scratch. That being a very unlikely prospect these days, the next best thing is to avoid the following:

  • Low-fat and low-salt products, especially dairy and dairy substitutes;
  • Chicken nuggets, along with any other “formed” meat products;
  • Expensive cuts of meat being sold much cheaper than they should be (that especially is true for restaurants);
  • Sushi from unreliable sources, formed fish sticks and balls;
  • Veggie and tofu burgers; and
  • Cheaply produced pasta (TG is said to help when using “damaged wheat flour”).

When asked what he would consider to be an important take-away regarding transglutaminase, Professor Lerner told us that it would be for the FDA to “reconsider the classification of (manufactured) TG as GRAS.”


If you have questions or comments, we’d love to hear from you. If you have hints for others on how to avoid exposure to MfG, send them along, too, and we’ll put them up on Facebook. Or you can reach us at questionsaboutmsg@gmail.com and follow us on Twitter @truthlabeling.

Don’t get tangled up in MSG’s web of deception

The web is a treacherous place.  And the marketing done to sell toxic food additives may be the most dangerous territory of all.

According to Stanford University Professor Sam Wineburg,1 an article’s bylined author may not be its author. References that confer legitimacy may have little to do with the claims they anchor. Signals of credibility like a dot-org domain can be the artful handiwork of a Washington, D.C. public relations expert.

Wineburg cautions that unless you possess multiple Ph.D.’s – in virology, economics and the intricacies of immigration policy– often the wisest thing to do when landing on an unfamiliar site is to ignore it.2

Through years of painful experience, I have learned that posts about any “controversial” subject may harbor deceptive and misleading statements, half-truths, and affirmations from “experts” or “celebrities” who know nothing about the subject or are being generously “thanked” for their participation.  Not to be overlooked are details behind the controversy left untold.

In his article, Wineburg tells us that “Learning to ignore information is not something taught in school. School teaches the opposite: to read a text thoroughly and closely before rendering judgment. Anything short of that is rash.  But on the web, where a witches’ brew of advertisers, lobbyists, conspiracy theorists and foreign governments conspire to hijack attention, the same strategy spells doom. Online, critical ignoring is just as important as critical thinking.” 

The “controversial” story I know a lot about is the story about the alleged safety of monosodium glutamate (a.k.a. MSG).  The stories told about MSG and its toxic constituent, manufactured free glutamate (MfG) have two arms.  The first arm reaches out to you with warm fuzzy feel-good words that trigger visions of delicious, savory food, all due, so you are told, to this flavor enhancer that is being promoted.

The second arm that Wineburg was talking about brings you words designed to convince skeptics that MSG is a harmless, even beneficial, food additive.  And that arm extends out to TV, YouTube, and print media and embraces the Internet.

A stunning example recently appeared in an article titled Food Science Babe: MSG myths persist despite decades of research.  It was published on 5/13/2021 at the website agdaily.com, which is quite an interesting story all on its own. But more about that another time.

Adrienne Samuels

References

1. Sam Wineburg, Professor of Education and (by courtesy) History, Stanford University

2. https://theconversation.com/to-navigate-the-dangers-of-the-web-you-need-critical-thinking-but-also-critical-ignoring-158617 (Accessed 5/15/2021)

About The Truth in Labeling Campaign

The Truth in Labeling Campaign was incorporated in 1994 as a nonprofit organization dedicated to securing full and clear labeling of all processed food.

We are an all-volunteer group funded entirely through donations. Neither our staff nor our directors are paid. We rent no offices, and we use no professional fund raisers. Even the cost of disseminating information is primarily borne by volunteers. Our activities, many described in our website at: www.truthinlabeling.org, have included visits to congresspersons and scientists, attendance at food industry meetings, testimony before representatives of the U.S. Food and Drug Administration (FDA), and filing a lawsuit against the FDA.

But more importantly, we have been making information on the toxic potential of MSG and where it is hidden in food, pharmaceuticals, cosmetics, dietary supplements, pesticides and fertilizers and vaccines, available to consumers.

This organization was founded by Jack Samuels, a health care professional who had an acute, life-threatening sensitivity to MSG, and Adrienne Samuels, an experimental psychologist by training with expertise in research design, methodology, and statistics. Both had the skills needed to understand the science underlying Jack’s life-threatening sensitivity, along with the ability to distinguish between the fact of his sensitivity and the fiction generated by those who profit from the manufacture and sale of MSG. Adrienne possessed the knowhow to recognize design flaws in research reports – including those research reports that claimed to have found that MSG is “safe.” The first (and ongoing) project of The Truth in Labeling Campaign (TLC) was to secure identification of processed free glutamic acid (MSG) whenever and wherever it occurs.

For over 30 years, concerned consumers have tried to work with the FDA to resolve this identification issue, but have found no evidence that the FDA is ever going to act on their behalf. It appears that only through a true grassroots effort might the FDA’s refusal to require labeling of MSG be resolved. It was with this in mind that the TLC joined with 29 petitioners, whose ranks included physicians, researchers, and parents acting on behalf of their MSG-sensitive children, to file a Citizen Petition asking the FDA to require labeling of all MSG found in processed foods.

The Citizen Petition was followed by a lawsuit that the FDA easily had set aside. The FDA had only to invoke the Administrative Procedures Act (APA), which allows agencies of the U.S. government to tell the court what material it may or may not look at. Through use of the APA, the FDA was able to withhold evidence contained in its own files that testifies to the fact that MSG has toxic potential.


If you have questions or comments, we’d love to hear from you. If you have hints for others on how to avoid exposure to MfG, send them along, too, and we’ll put them up on Facebook. Or you can reach us at questionsaboutmsg@gmail.com and follow us on Twitter @truthlabeling.